TY  - JOUR
A1  - Schlaphoff, Verena
A1  - Lunemann, Sebastian
A1  - Suneetha, Pothakamuri Venkata
A1  - Jaroszewicz, Jerzy
A1  - Grabowski, Jan
A1  - Dietz, Julia
A1  - Helfritz, Fabian Arnold
A1  - Bektas, Hueseyin
A1  - Sarrazin, Christoph
A1  - Manns, Michael P.
A1  - Cornberg, Markus
A1  - Wedemeyer, Heiner
T1  - Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells
T2  - PLoS pathogens
N2  - The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed by CD8+ T cells. The aim of this study was to analyze the role of 2B4 as an additional costimulatory receptor regulating CD8+ T cell function and in particular to investigate its implication for exhaustion of hepatitis C virus (HCV)-specific CD8+ T cells during persistent infection. We demonstrate that (i) 2B4 is expressed on virus-specific CD8+ T cells during acute and chronic hepatitis C, (ii) that 2B4 cross-linking can lead to both inhibition and activation of HCV-specific CD8+ T cell function, depending on expression levels of 2B4 and the intracellular adaptor molecule SAP and (iii) that 2B4 stimulation may counteract enhanced proliferation of HCV-specific CD8+ T cells induced by PD1 blockade. We suggest that 2B4 is another important molecule within the network of costimulatory/inhibitory receptors regulating CD8+ T cell function in acute and chronic hepatitis C and that 2B4 expression levels could also be a marker of CD8+ T cell dysfunction. Understanding in more detail how 2B4 exerts its differential effects could have implications for the development of novel immunotherapies of HCV infection aiming to achieve immune control.
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/22568
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-114233
SN  - 1553-7374
N1  - Copyright: © 2011 Schlaphoff et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 7
IS  - (5): e1002045
SP  - 1
EP  - 14
PB  - PLoS
CY  - Lawrence, Kan.
ER  -