TY  - JOUR
A1  - Verring, A.
A1  - Clouth, Aline
A1  - Ziolkowski, Piotr
A1  - Oremek, Gerhard
T1  - Clinical usefulness of cancer markers in primary breast cancer
T2  - ISRN pathology
N2  - The aim of this study was to investigate the diagnostic power of CA 549, MSA and CA 15-3 in identifying breast cancer. The study included 232 patients of which 56 were healthy, 43 had benign breast cancer and 191 with other growths. The results were obtained using a specific immunoassay and using producers' cut offs. The following sensitivity and specificity of markers were found: CA 549 (sen.: 40%/spec.: 90%), MSA (sen.: 22%/spec.: 96%), and CA 15-3 (sen.: 33%/spec.: 86%). Ideal cut offs were defined with ROC curves. A significant correlation was found between CA 549, MSA, and CA 15-3. The combination of markers does not improve the clinical usefulness to identify only breast cancer. Serum tumor markers are abnormally elevated in patients with breast cancer. CA 549, MSA, CA 15-3 are useful clinical markers, good indicators of disease extent, and may have important prognostic value. This study demonstrates the role of the tumor markers in breast cancer.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28612
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-286129
SN  - 2090-5718
SN  - 2090-570X
N1  - Copyright © 2011 A. Verring et al. This is an open access article distributed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2011
IS  - Article ID 817618
PB  - Hindawi
CY  - New York, NY [u.a.]
ER  -