TY  - JOUR
A1  - Gracien, René-Maxime
A1  - Jurcoane, Alina
A1  - Wagner, Marlies
A1  - Reitz, Sarah
A1  - Mayer, Christoph
A1  - Volz, Steffen
A1  - Hof, Stephanie-Michelle
A1  - Fleischer, Vinzenz
A1  - Droby, Amgad
A1  - Steinmetz, Helmuth
A1  - Zipp, Frauke
A1  - Hattingen, Elke
A1  - Deichmann, Ralf
A1  - Klein, Johannes Christian
T1  - The relationship between gray matter quantitative MRI and disability in secondary progressive multiple sclerosis
T2  - PLoS One
N2  - Purpose: In secondary progressive Multiple Sclerosis (SPMS), global neurodegeneration as a driver of disability gains importance in comparison to focal inflammatory processes. However, clinical MRI does not visualize changes of tissue composition outside MS lesions. This quantitative MRI (qMRI) study investigated cortical and deep gray matter (GM) proton density (PD) values and T1 relaxation times to explore their potential to assess neuronal damage and its relationship to clinical disability in SPMS.
Materials and Methods: 11 SPMS patients underwent quantitative T1 and PD mapping. Parameter values across the cerebral cortex and deep GM structures were compared with 11 healthy controls, and correlation with disability was investigated for regions exhibiting significant group differences.
Results: PD was increased in the whole GM, cerebral cortex, thalamus, putamen and pallidum. PD correlated with disability in the whole GM, cerebral cortex, putamen and pallidum. T1 relaxation time was prolonged and correlated with disability in the whole GM and cerebral cortex.
Conclusion: Our study suggests that the qMRI parameters GM PD (which likely indicates replacement of neural tissue with water) and cortical T1 (which reflects cortical damage including and beyond increased water content) are promising qMRI candidates for the assessment of disease status, and are related to disability in SPMS.
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/41440
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-414406
SN  - 1932-6203
N1  - Copyright: © 2016 Gracien et al. This is an open access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 11
IS  - (8): e0161036
SP  - 1
EP  - 14
PB  - PLoS
CY  - Lawrence, Kan.
ER  -