TY  - JOUR
A1  - Schwarzkopf, Katharina
A1  - Queck, Alexander David Roger
A1  - Thomas, Dominique Jeanette
A1  - Angioni, Carlo Federico
A1  - Cai, Chengcong
A1  - Freygang, Ylva
A1  - Rüschenbaum, Sabrina
A1  - Geisslinger, Gerd
A1  - Zeuzem, Stefan
A1  - Welsch, Christoph
A1  - Lange, Christian Michael
T1  - Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
T2  - PLoS one
N2  - Background: Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors of pro-resolving mediators and support the resolution of inflammation.
Objective: The aim of this study was to determine plasma levels of omega-3 fatty acids in patients with liver cirrhosis and ACLF.
Methods: Patients with liver cirrhosis with and without ACLF were enrolled in a prospective cohort study and analyzed post-hoc for the present sub-study. Clinical data and biomaterials were collected at baseline and at day 7, 28 and after 3 months of follow-up. Plasma concentrations of arachidonic acid (ARA) and docosahexaenoic acid (DHA), which represent key omega-6 and -3 fatty acids, respectively, were quantified and associated with markers of systemic inflammation and severity of liver cirrhosis.
Results: A total of 117 patients were included in the present analyses. Of those, 26 (22.2%), 51 (43.6%) and 40 (34.2%) patients had compensated or decompensated liver cirrhosis, and ACLF. Plasma levels of ARA and DHA were similar in patients with compensated cirrhosis, decompensated cirrhosis, and ACLF. Furthermore, no significant association between plasma ARA or DHA and C-reactive protein or peripheral blood leukocytes were observed (P>0.05).
Conclusion: In our study plasma levels of key omega-3 and omega-6 fatty acid are neither associated with the severity of liver cirrhosis nor with liver-cirrhosis-associated systemic inflammation.
KW  - Cirrhosis
KW  - Blood plasma
KW  - Inflammation
KW  - Fatty acids
KW  - Fatty liver
KW  - Liver
KW  - Liver diseases
KW  - Eicosanoids
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48847
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-488479
SN  - 1932-6203
N1  - Copyright: © 2019 Schwarzkopf et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 14
IS  - (1): e0211537
SP  - 1
EP  - 10
PB  - PLoS
CY  - Lawrence, Kan.
ER  -