TY  - JOUR
A1  - Schaller-Paule, Martin A.
A1  - Förch, Christian
A1  - Kluge, Sara
A1  - Baumgarten, Peter
A1  - Konczalla, Jürgen
A1  - Steinbach, Joachim Peter
A1  - Wagner, Marlies
A1  - Luger, Anna-Luisa
T1  - Delayed occurrence of hypertrophic olivary degeneration after therapy of posterior fossa tumors: A single institution retrospective analysis
T2  - Journal of Clinical Medicine
N2  - (1) Background: A lesion within the dentato-rubro-olivary pathway (DROP) in the posterior fossa can cause secondary neurodegeneration of the inferior olivary nucleus: so-called hypertrophic olivary degeneration (HOD). The clinical syndrome of HOD occurs slowly over months and may be overlooked in progressive neuro-oncological diseases. Posterior fossa tumors are often located near these strategic structures. The goal of this study was to analyze the systematics of HOD occurrence in neuro-oncological patients.
(2) Methods: The neuroradiological database of the university healthcare center was scanned for HOD-related terms from 2010 to 2019. After excluding patients with other causes of HOD, 12 datasets from neuro-oncological patients were analyzed under predetermined criteria.
(3) Results: Patients received multimodal tumor treatments including neurosurgery, radiotherapy, and chemotherapy. HOD occurred both unilaterally (left n = 4; right n = 5) and bilaterally (n = 3). Though the mass effect of posterior fossa tumors had already affected strategic structures of the DROP, none of the patients showed signs of HOD on MRI until therapeutic measures including neurosurgery affecting the DROP were applied. HOD was visible on MRI within a median of 6 months after the neurosurgical intervention. In 67%, the presumed underlying surgical lesion in the DROP lay in the contralateral dentate nucleus.
(4) Conclusion: In a selected cohort of neuro-oncological patients, therapeutic lesions within the DROP were associated with HOD occurrence.
KW  - palatal tremor
KW  - posterior fossa masses
KW  - Holmes tremor
KW  - medulloblastoma resection
KW  - HOD
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/52751
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-527512
SN  - 2077-0383
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 8
IS  - 12, Art. 2222
SP  - 1
EP  - 11
PB  - MDPI
CY  - Basel
ER  -