TY  - JOUR
A1  - König, Klemens
A1  - Köhler, David
A1  - Granja, Tiago
A1  - Jennewein, Carla
A1  - Tran, Thi Hoai Nguyen
A1  - Mirakaj, Valbona
A1  - Kröhnert, Friedemann
A1  - Rosenberger, Peter
T1  - The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury
T2  - PLoS One
N2  - Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of UNC5B during an acute inflammatory response we investigated the role of UNC5B on acute hepatic IRI. We report here that UNC5B+/− mice display reduced hepatic IRI and neutrophil (PMN) infiltration compared to WT controls. This correlated with serum levels of lactate dehydrogenase (LDH), aspartate- (AST) and alanine- (ALT) aminotransferase, the presence of PMN within ischemic hepatic tissue, and serum levels of inflammatory cytokines. Moreover, injection of an anti-UNC5B antibody resulted in a significant reduction of hepatic IR injury. This was associated with reduced parameters of liver injury (LDH, ALT, AST) and accumulation of PMN within the injured hepatic tissue. In conclusion our studies demonstrate a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25727
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-257276
SN  - 1932-6203
VL  - 7
IS  - (7):e41085
PB  - PLoS
CY  - Lawrence, Kan.
ER  -