TY  - JOUR
A1  - Mingomataj, Ervin
A1  - Priftanji, Alfred
A1  - Qirko, Etleva
A1  - Dinh, Q. Thai
A1  - Fischer, Axel
A1  - Peiser, Christian
A1  - Groneberg, Jan David Alexander
T1  - Specific immunotherapy in Albanian patients with anaphylaxis to hymenoptera venoms
T2  - BMC dermatology
N2  - Background: Severe allergic reactions during rush-specific immunotherapy (Rush-SIT) may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during Rush-SIT in a cohort of patients with allergy towards hymenoptera venom in the mediterranean population of Albania.
Methods: A retrospective study was performed using the clinical reports of 37 patients with venom of bee (apinae), wasp (vespidae, subfamily vespinae) or paperwasp (vespidae, subfamily polistinae) allergy treated with Rush-SIT between 1987 and 1996. After hymenoptera sting allergy diagnosis according to anamnesis and intracutaneous tests the patient were treated with Rush-SIT. The protocol lasted 3 - 4 d with an increase in the concentration from 0.01 microg/ml to 100 microg/ml. Anaphylactic reactions were classified according to the Mueller-classification.
Results: The frequency of reactions during Rush-SIT for bee-venom was 4.7% and for wasp-venom was 1.5% (p < 0.01). The mean frequency of reactions of Mueller grade II for the bee-venom Rush-SIT patients during the first 4 d (= 26 injections) was 0.73 and for the wasp-venom Rush-SIT patients 0.15. No patient experienced a third-degree reaction. 94.6% of the patient supported an end dose of 100 microg.
Conclusions: Rush-SIT is a reliable method for the treatment of anaphylactic reactions to hymenoptera venom even in less developed countries. Bee-venom Rush-SIT was found to cause higher numbers allergic reactions than wasp or paperwasp Rush-SIT.
KW  - hymenoptera
KW  - Rush
KW  - Rush-SIT
KW  - anaphylactic reactions
Y1  - 2002
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25807
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-258070
SN  - 1471-5945
VL  - 2
IS  - 11
PB  - BioMed Central
CY  - London
ER  -