TY  - JOUR
A1  - Krim, Jamal
A1  - Taourirte, Mohamed
A1  - Engels, Joachim W.
T1  - Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition
T2  - Molecules
N2  - A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the azido-pseudo-sugar 4-azidobutylacetate under solvent-free microwave conditions, followed by treatment with K2CO3/MeOH, or NH3/MeOH. All compounds studied in this work were screened for their antiviral activities [against human rhinovirus (HRV) and hepatitis C virus (HCV)] and antibacterial activities against a series of Gram positive and negative bacteria.
KW  - 1,3-dipolar cycloaddition
KW  - 1,2,3 triazole
KW  - 1,2,3-bis-triazoles
KW  - click azide-alkyne
KW  - microwave-assisted synthesis
KW  - antibacterial activities
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25939
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-259394
SN  - 1420-3049
N1  - © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 17
IS  - 1
SP  - 179
EP  - 190
PB  - Molecular Diversity Preservation International (MDPI)
CY  - Basel
ER  -