TY  - JOUR
A1  - Kendel, Yvonne
A1  - Melaun, Christian
A1  - Kurz, Alexander
A1  - Nicke, Annette
A1  - Peigneur, Steve
A1  - Tytgat, Jan
A1  - Wunder, Cora
A1  - Mebs, Dietrich
A1  - Kauferstein, Silke
T1  - Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors
T2  - Toxins
N2  - Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects of venom and gland extracts from three species of the superfamily Terebridae. By 2-electrode voltage-clamp technique the gland extracts were tested on Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) of rat neuronal (α3β2, α3β4, α4β2, α4β4, α7) and muscle subtypes (α1β1γδ), and expressing potassium (Kv1.2 and Kv1.3) and sodium channels (Nav1.2, 1.3, 1.4, 1.6). The extracts were shown to exhibit remarkably high inhibitory activities on almost all nAChRs tested, in particular on the α7 subtype suggesting the presence of peptides of the A-superfamily from the venom of Conus species. In contrast, no effects on the potassium and sodium channels tested were observed. The venoms of terebrid snails may offer an additional source of novel biologically active peptides.
KW  - terebridae venom
KW  - gland extracts
KW  - acetylcholine receptors
KW  - potassium channels
KW  - sodium channels
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26346
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-263468
SN  - 2072-6651
N1  - © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 5
IS  - 5
SP  - 1043
EP  - 1050
PB  - Molecular Diversity Preservation Internat. (MDPI)
CY  - Basel
ER  -