TY  - JOUR
A1  - Gfrörer, Stefan
A1  - Fiegel, Henning C.
A1  - Ramachandran, Priya
A1  - Rolle, Udo
A1  - Metzger, Roman
T1  - Changes of smooth muscle contractile filaments in small bowel atresia
T2  - World journal of gastroenterology : WJG
N2  - AIM: To investigate morphological changes of intestinal smooth muscle contractile fibres in small bowel atresia patients. METHODS: Resected small bowel specimens from small bowel atresia patients (n = 12) were divided into three sections (proximal, atretic and distal). Standard histology hematoxylin-eosin staining and enzyme immunohistochemistry was performed to visualize smooth muscle contractile markers α-smooth muscle actin (SMA) and desmin using conventional paraffin sections of the proximal and distal bowel. Small bowel from age-matched patients (n = 2) undergoing Meckel's diverticulum resection served as controls.
RESULTS: The smooth muscle coat in the proximal bowel of small bowel atresia patients was thickened compared with control tissue, but the distal bowel was unchanged. Expression of smooth muscle contractile fibres SMA and desmin within the proximal bowel was slightly reduced compared with the distal bowel and control tissue. There were no major differences in the architecture of the smooth muscle within the proximal bowel and the distal bowel. The proximal and distal bowel in small bowel atresia patients revealed only minimal differences regarding smooth muscle morphology and the presence of smooth muscle contractile filament markers.
CONCLUSION: Changes in smooth muscle contractile filaments do not appear to play a major role in postoperative motility disorders in small bowel atresia.
KW  - Enteric nervous system
KW  - Motility disorder
KW  - Small bowel atresia
KW  - Smooth muscle
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31211
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-312118
SN  - 2219-2840
SN  - 1007-9327
N1  - WJG is an international, peer-reviewed, Open-Access, online journal. Articles published by this journal are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.
VL  - 18
IS  - 24
SP  - 3099
EP  - 3104
PB  - WJG Press
CY  - Beijing
ER  -