TY  - JOUR
A1  - Reinke, Britta
A1  - Ven, Vincent van de
A1  - Matura, Silke
A1  - Linden, David
A1  - Oertel-Knöchel, Viola
T1  - Altered intrinsic functional connectivity in language-related brain regions in association with verbal memory performance in euthymic bipolar patients
T2  - Brain Sciences
N2  - Potential abnormalities in the structure and function of the temporal lobes have been studied much less in bipolar disorder than in schizophrenia. This may not be justified because language-related symptoms, such as pressured speech and flight of ideas, and cognitive deficits in the domain of verbal memory are amongst the hallmark of bipolar disorder (BD), and contribution of temporal lobe dysfunction is therefore likely. In the current study, we examined resting-state functional connectivity (FC) between the auditory cortex (Heschl’s gyrus [HG], planum temporale [PT]) and whole brain using seed correlation analysis in n = 21 BD euthymic patients and n = 20 matched healthy controls and associated it with verbal memory performance. In comparison to controls BD patients showed decreased functional connectivity between Heschl’s gyrus and planum temporale and the left superior and middle temporal gyrus. Additionally, fronto-temporal functional connectivity with the right inferior frontal/precentral gyrus and the insula was increased in patients. Verbal episodic memory deficits in the investigated sample of BD patients and language-related symptoms might therefore be associated with a diminished FC within the auditory/temporal gyrus and a compensatory fronto-temporal pathway.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31649
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-316497
SN  - 2076-3425
N1  - © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 3
IS  - 3
SP  - 1357
EP  - 1373
PB  - MDPI AG
CY  - Basel
ER  -