TY  - JOUR
A1  - Kasama, Yuri
A1  - Mizukami, Takuo
A1  - Kusunoki, Hideki
A1  - Peveling-Oberhag, Jan Franz-Josef
A1  - Nishito, Yasumasa
A1  - Ozawa, Makoto
A1  - Kohara, Michinori
A1  - Mizuochi, Toshiaki
A1  - Tsukiyama-Kohara, Kyoko
T1  - B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling
T2  - PLoS One
N2  - Hepatitis C virus (HCV) infection leads to the development of hepatic diseases, as well as extrahepatic disorders such as B-cell non-Hodgkin's lymphoma (B-NHL). To reveal the molecular signalling pathways responsible for HCV-associated B-NHL development, we utilised transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-developing HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analysed by genome-wide microarray. In BCLs from HCV-Tg mice, the expression of various genes was modified, and for some genes, expression was influenced by the gender of the animals. Markedly modified genes such as Fos, C3, LTβR, A20, NF-κB and miR-26b in BCLs were further characterised using specific assays. We propose that activation of both canonical and alternative NF-κB signalling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/33345
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-333454
SN  - 1932-6203
N1  - Copyright: © 2014 Kasama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (3):e91373
PB  - PLoS
CY  - Lawrence, Kan.
ER  -