TY  - JOUR
A1  - Hallström, Teresia
A1  - Singh, Birendra
A1  - Kraiczy, Peter
A1  - Hammerschmidt, Sven
A1  - Skerka, Christine
A1  - Zipfel, Peter F.
A1  - Riesbeck, Kristian
T1  - Conserved patterns of microbial immune escape : pathogenic microbes of diverse origin target the human terminal complement inhibitor vitronectin via a single common motif
T2  - PLoS One
N2  - Pathogenicity of many microbes relies on their capacity to resist innate immunity, and to survive and persist in an immunocompetent human host microbes have developed highly efficient and sophisticated complement evasion strategies. Here we show that different human pathogens including Gram-negative and Gram-positive bacteria, as well as the fungal pathogen Candida albicans, acquire the human terminal complement regulator vitronectin to their surface. By using truncated vitronectin fragments we found that all analyzed microbial pathogens (n = 13) bound human vitronectin via the same C-terminal heparin-binding domain (amino acids 352–374). This specific interaction leaves the terminal complement complex (TCC) regulatory region of vitronectin accessible, allowing inhibition of C5b-7 membrane insertion and C9 polymerization. Vitronectin complexed with the various microbes and corresponding proteins was thus functionally active and inhibited complement-mediated C5b-9 deposition. Taken together, diverse microbial pathogens expressing different structurally unrelated vitronectin-binding molecules interact with host vitronectin via the same conserved region to allow versatile control of the host innate immune response.
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/39049
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-390494
SN  - 1932-6203
N1  - Copyright: © 2016 Hallström et al. This is an open access article distributed under the terms of the Creative Commons Attribution License  http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 11
IS  - (1): e0147709
SP  - 1
EP  - 17
PB  - PLoS
CY  - Lawrence, Kan.
ER  -