TY  - JOUR
A1  - Brüning, Jürgen
A1  - Trepte, Tanja K.
A1  - Bats, Jan W.
A1  - Schmidt, Martin Ulrich
T1  - Erythromycin A di­methyl sulfoxide disolvate 1.43-hydrate
T2  - Acta crystallographica. Section E, Structure reports online, 68.2012, S. o700-o701
N2  - The title compound, C37H67NO13·2C2H6OS·1.43H2O, is a macrolide anti­biotic with better solubility and better dermal penetration abilities than erythromycin A itself. The asymmetric unit of this form contains one erythromycin A mol­ecule, two dimethyl sulfoxide (DMSO) solvent mol­ecules, a fully occupied water mol­ecule and a partially occupied water mol­ecule with an occupancy factor of 0.432 (11). The 14-membered ring of the erythronolide fragment has a conformation which differs considerably from that in erythromycin A dihydrate [Stephenson, Stowell, Toma, Pfeiffer & Byrn (1997[Stephenson, G. A., Stowell, J. G., Toma, P. H., Pfeiffer, R. R. & Byrn, S. R. (1997). J. Pharm. Sci. 86, 1239-1244.]). J. Pharm. Sci. 86, 1239–1244]. One of the two DMSO mol­ecules is disordered over two orientations; the orientation depends on the presence or absence of the second, partially occupied, water mol­ecule. In the crystal, erythromycin mol­ecules are connected by O—H⋯O hydrogen bonds involving the hy­droxy groups and the fully occupied water mol­ecule to form layers parallel to (010). These layers are connected along the b-axis direction only by a possible hydrogen-bonding contact involving the partially occupied water mol­ecule.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/39230
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-392309
SN  - 1600-5368
N1  - This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence http://creativecommons.org/licenses/by/2.0/uk/legalcode , which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
VL  - 68
IS  - o700-o701
PB  - International Union of Crystallography
CY  - Chester
ER  -