TY  - JOUR
A1  - Hrgovic, Igor
A1  - Hartmann, Sylvia
A1  - Steffen, Björn
A1  - Vogl, Thomas J.
A1  - Kaufmann, Roland
A1  - Meissner, Markus
T1  - Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: a case report and review of the literature
T2  - Molecular and clinical oncology
N2  - Mantle cell lymphoma (MCL) is a unique type of B-cell non-Hodgkin's lymphoma, which very rarely exhibits skin involvement. We herein describe the case of a 55-year-old woman, who initially presented with a nodular mass of the right infraorbital region. On histological analysis of the subcutaneous tissue, a diffuse neoplastic cell infiltration was identified, composed of medium‑sized lymphoid cells with irregular nuclei, which was diagnosed as MCL. The tumor cells were positive for CD5, CD20, CD79a, cyclin D1 and sex‑determining region Y-box 11, but negative for CD10 and CD23. Our patient received six cycles of R‑CHOP chemotherapy and intrathecal methotrexate as central nervous system prophylaxis. However, the patient relapsed 1 year later and was treated with two cycles of R‑DHAP and one cycle of intrathecal methotrexate. After achieving partial remission, the patient was consolidated with peripheral blood stem cell transplantation using the BEAM conditioning regime. While prior case studies suggest that skin invasion by MCL is associated with a poor prognosis, our patient remains alive almost 4 years after the initial presentation. Skin involvement as a first sign of systemic MCL is very rare and must be considered.
KW  - mantle cell lymphoma
KW  - non‑Hodgkin's lymphoma
KW  - sex‑determining region Y-box 11
KW  - skin involvement
KW  - peripheral blood stem cell transplant
KW  - retuximab
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42256
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-422566
SN  - 2049-9450
SN  - 2049-9469
N1  - © Hrgovic et al. This is an open access article distributed under the terms of Creative Commons Attribution License https://creativecommons.org/licenses/by-nc-nd/4.0/ .
VL  - 4
IS  - 5
SP  - 728
EP  - 732
PB  - Spandidos Publ.
CY  - Athens
ER  -