TY  - JOUR
A1  - Schmidtko, Achim
A1  - Tegeder, Irmgard
A1  - Niederberger, Ellen
A1  - Hofmann, Franz
A1  - Ruth, Peter
A1  - Geisslinger, Gerd
T1  - The role of cGMP and PKG-I in spinal nociceptive processing
T2  - BMC pharmacology
N2  - First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia. The release of NO and subsequent synthesis of cGMP in the spinal cord are involved in this process. cGMP-dependent protein kinase I (PKG-I) has been suggested to act as a downstream target of cGMP, but its exact role in nociception hadn't been characterized yet. To further evaluate the NO/cGMP/PKG-I pathway in nociception we assessed the effects of PKG-I inhibiton and activaton in the rat formalin assay and analyzed the nociceptive behavior of PKG-I-/- mice. Open access article.
Y1  - 2005
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/4334
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-11521
UR  - https://bmcpharma.biomedcentral.com/articles/10.1186/1471-2210-5-S1-P50
SN  - 1471-2210
N1  - Copyright: © BioMed Central Ltd 2005
VL  - 5
IS  - (Suppl 1):P50
SP  - 1
EP  - 1
PB  - BioMed Central
CY  - London
ER  -