TY  - JOUR
A1  - Thieme, Karl G.
A1  - Gerke, Jennifer
A1  - Sasse, Christoph
A1  - Valerius, Oliver
A1  - Thieme, Sabine
A1  - Karimi, Razieh
A1  - Heinrich, Antje Katharina
A1  - Finkernagel, Florian
A1  - Smith, Kristina
A1  - Bode, Helge Björn
A1  - Freitag, Michael
A1  - Ram, Arthur F. J.
A1  - Braus, Gerhard H.
T1  - Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism
T2  - PLoS Genetics
N2  - The NF-κB-like velvet domain protein VosA (viability of spores) binds to more than 1,500 promoter sequences in the filamentous fungus Aspergillus nidulans. VosA inhibits premature induction of the developmental activator gene brlA, which promotes asexual spore formation in response to environmental cues as light. VosA represses a novel genetic network controlled by the sclB gene. Bfunction is antagonistic to VosA, because it induces the expression of early activator genes of asexual differentiation as flbC and flbD as well as brlA. The SclB controlled network promotes asexual development and spore viability, but is independent of the fungal light control. SclB interactions with the RcoA transcriptional repressor subunit suggest additional inhibitory functions on transcription. SclB links asexual spore formation to the synthesis of secondary metabolites including emericellamides, austinol as well as dehydroaustinol and activates the oxidative stress response of the fungus. The fungal VosA-SclB regulatory system of transcription includes a VosA control of the sclB promoter, common and opposite VosA and SclB control functions of fungal development and several additional regulatory genes. The relationship between VosA and SclB illustrates the presence of a convoluted surveillance apparatus of transcriptional control, which is required for accurate fungal development and the linkage to the appropriate secondary metabolism.
KW  - Aspergillus nidulans
KW  - Gene expression
KW  - Fungal genetics
KW  - Gene regulation
KW  - Transcription factors
KW  - Fungal spores
KW  - Oxidative stress
KW  - Secondary metabolism
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46861
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-468611
SN  - 1553-7404
SN  - 1553-7390
N1  - Copyright: © 2018 Thieme et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
N1  - Correction erschienen in: PLoS Genetics, volume 14, issue 8, e1007638 (2018), doi:10.1371/journal.pgen.1007638
VL  - 14
IS  - (7): e1007511
SP  - 1
EP  - 45
PB  - Public Library of Science
CY  - San Francisco, Calif.
ER  -