TY - JOUR A1 - Liu, Yi A1 - Guo, Zhibin A1 - Zhao, Chenlong A1 - Li, Xin A1 - Liu, Hongyu A1 - Chen, Jun T1 - Lymphangioleiomyomatosis : a case report and review of diagnosis and treatment T2 - OncoTargets and therapy N2 - Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer and pulmonary LAM, especially during early stages. Herein, we present a case of a 66-year-old man with a small nodule in the right upper lobe that was first diagnosed as a lung malignancy using a chest CT scan. After a wedge dissection, a pathologist performed a histologic and immunohistochemical examination, and a diagnosis of pulmonary LAM was made. We further performed a 518-gene panel analysis using next-generation sequencing, and only three genes, BARD1, BLM, and BRCA2, were found to have mutations. We also provide a summary of the diagnosis and treatment of this disease. KW - lymphangioleiomyomatosis KW - lung cancer KW - diagnosis and treatment Y1 - 2018 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48437 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-484371 SN - 1178-6930 N1 - This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. VL - 11 SP - 5339 EP - 5347 PB - Dove Medical Press CY - Albany, Auckland ER -