TY  - JOUR
A1  - Baltes, Peter
A1  - Bota, Marc
A1  - Albert, Jörg Gerhard
A1  - Philipper, Michael
A1  - Hörster, Hans-Georg
A1  - Hagenmüller, Friedrich
A1  - Steinbrück, Ingo
A1  - Jakobs, Ralf
A1  - Bechtler, Matthias
A1  - Hartmann, Dirk
A1  - Neuhaus, Horst
A1  - Charton, Jean-Pierre
A1  - Mayershofer, Rupert
A1  - Hohn, Horst
A1  - Rösch, Thomas
A1  - Groth, Stefan
A1  - Nowak, Tanja
A1  - Wohlmuth, Peter
A1  - Keuchel, Martin
T1  - PillCamColon2 after incomplete colonoscopy - a prospective multicenter study
T2  - World journal of gastroenterology
N2  - Aim: To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy (OC) and to assess the diagnostic yield.
Methods: This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy (CCE) following incomplete OC performed by an experienced gastroenterologist (> 1000 colonoscopies). Patients with stenosis were excluded. According to patient preferences, CCE was performed the following day (protocol A) after staying on clear liquids and 0.75 L Moviprep in the morning or within 30 d after new split-dose Moviprep (protocol B). Boosts consisted of 0.75 L and 0.25 L Moviprep, and phospho-soda was given as a rescue if the capsule was not excreted after seven hours.
Results: Seventy-four patients were analysed (51% of them in group A; 49% in group B). Bowel cleansing was adequate in 67% of cases, and CCE could visualize colonic segments missed by incomplete colonoscopy in 90% of patients under protocol A and 97% of patients under protocol B (P = 0.35, n.s.). Significant polyps including adenocarcinoma were detected in 24% of cases. Detection rates for all polyps and significant polyps per patient were similar in both protocols. Polyps were found predominantly in the right colon (86%) in segments that were not reached by OC. Extracolonic findings - such as reflux esophagitis, suspected Barrett esophagus, upper GI-bleeding, gastric polyps, gastric erosions and angiectasia - were detected in eight patients. PillCamColon2 capsule was retained in the ileum of one patient (1.4%) without symptoms and removed during an uneventful resection for unknown Crohn’s disease that was diagnosed as the cause of anemia, which was the indication for colonoscopy. CCE was well tolerated. One patient suffered from self-limiting vomiting after consuming the phospho-soda.
Conclusion: Second-generation CCE using a low-volume preparation is useful after incomplete OC, and it allows for the detection of additional relevant findings, but cleansing efficiency could be improved.
KW  - Colon capsule endoscopy
KW  - PillCamColon2
KW  - Incomplete colonoscopy
KW  - Low volume prep
KW  - Moviprep
KW  - Phospho-soda
KW  - Cleanliness level
KW  - Complementation rate
KW  - Polyps
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48464
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-484646
SN  - 2219-2840
SN  - 1007-9327
N1  - Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
VL  - 24
IS  - 31
SP  - 3556
EP  - 3566
PB  - WJG Press
CY  - Beijing
ER  -