TY  - JOUR
A1  - Krimphove, Marieke Johanna
A1  - Theißen, Lena
A1  - Cole, Alexander P.
A1  - Preißer, Felix Martin
A1  - Mandel, Philipp
A1  - Chun, Felix
T1  - Performance and impact of prostate specific membrane antigen-based diagnostics in the management of men with biochemical recurrence of prostate cancer and its role in salvage lymph node dissection
T2  - The world journal of men's health
N2  - Up to 50% of patients initially treated for prostate cancer in a curative intent experience biochemical recurrence, possibly requiring adjuvant treatment. However, salvage treatment decisions, such as lymph node dissection or radiation therapy, are typically based on prostate specific antigen (PSA) recurrence. Importantly, common imaging modalities (e.g., computed tomography [CT], magnetic resonance imaging, and bone scan) are limited and the detection of recurrent disease is particularly challenging if PSA is low. Prostate specific membrane antigen (PSMA) positron-emission tomography/computed tomography (PET/CT) is a novel and promising imaging modality which aims to overcome the incapability of early identification of distant and regional metastases. Within this review, we summarize the current evidence related to PSMA-PET/CT in prostate cancer men diagnosed with biochemical recurrence after local treatment with curative intent. We discuss detection rates of PSMA-PET/CT stratified by PSA-levels and its impact on clinical decision making. Furthermore, we compare different imagefusion techniques such as PSMA-PET vs. F-/C-Choline-PET scans vs. PSMA-single photon emission computed tomography/CT. Finally, we touch upon the contemporary role of radio-guided-PSMA salvage lymphadenectomy.
KW  - Positron-emission tomography
KW  - Prostate-specific membrane antigen
KW  - human
KW  - Prostatic neoplasms
KW  - Salvage therapy
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48837
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-488373
SN  - 2287-4690
SN  - 2287-4208
N1  - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 37
IS  - e9
SP  - 1
EP  - 16
PB  - Korean Society for Sexual Medicine and Andrology
CY  - Busan
ER  -