TY  - JOUR
A1  - Kur, Ivan-Maximiliano
A1  - Prouvot, Pierre-Hugues
A1  - Fu, Ting
A1  - Fan, Wei
A1  - Müller-Braun, Felicia
A1  - Das, Avash
A1  - Das, Saumya
A1  - Deller, Thomas
A1  - Roeper, Jochen
A1  - Stroh, Albrecht
A1  - Momma, Stefan
T1  - Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo
T2  - PLoS biology
N2  - Communication with the hematopoietic system is a vital component of regulating brain function in health and disease. Traditionally, the major routes considered for this neuroimmune communication are by individual molecules such as cytokines carried by blood, by neural transmission, or, in more severe pathologies, by the entry of peripheral immune cells into the brain. In addition, functional mRNA from peripheral blood can be directly transferred to neurons via extracellular vesicles (EVs), but the parameters that determine their uptake are unknown. Using varied animal models that stimulate neuronal activity by peripheral inflammation, optogenetics, and selective proteasome inhibition of dopaminergic (DA) neurons, we show that the transfer of EVs from blood is triggered by neuronal activity in vivo. Importantly, this transfer occurs not only in pathological stimulation but also by neuronal activation caused by the physiological stimulus of novel object placement. This discovery suggests a continuous role of EVs under pathological conditions as well as during routine cognitive tasks in the healthy brain.
KW  - Neurons
KW  - Yellow fluorescent protein
KW  - Marker genes
KW  - Microglial cells
KW  - Gene expression
KW  - Intravenous injections
KW  - Optogenetics
KW  - Mouse models
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/53134
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-531348
SN  - 1545-7885
SN  - 1544-9173
N1  - Copyright: © 2020 Kur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 18
IS  - (3): e3000643
SP  - 1
EP  - 15
PB  - PLoS
CY  - Lawrence, KS
ER  -