TY  - JOUR
A1  - Bahls, Martin
A1  - Lorenz, Matthias W.
A1  - Dörr, Marcus
A1  - Gao, Lu
A1  - Kitagawa, Kazuo
A1  - Tuomainen, Tomi-Pekka
A1  - Agewall, Stefan
A1  - Berenson, Gerald
A1  - Catapano, Alberico L.
A1  - Norata, Giuseppe D.
A1  - Bots, Michiel L.
A1  - Gilst, Wiek van
A1  - Asselbergs, Folkert W.
A1  - Brouwers, Frank P.
A1  - Uthoff, Heiko
A1  - Sander, Dirk
A1  - Poppert, Holger
A1  - Hecht Olsen, Michael
A1  - Empana, Jean Philippe
A1  - Schminke, Ulf
A1  - Baldassarre, Damiano
A1  - Veglia, Fabrizio
A1  - Franco, Oscar H.
A1  - Kavousi, Maryam
A1  - Groot, Eric de
A1  - Mathiesen, Ellisiv B.
A1  - Grigore, Liliana
A1  - Polak, Joseph F.
A1  - Rundek, Tatjana
A1  - Stehouwer, Coen D. A.
A1  - Skilton, Michael R.
A1  - Hatzitolios, Apostolos I.
A1  - Savopoulos, Christos
A1  - Ntaios, George
A1  - Plichart, Matthieu
A1  - McLachlan, Stela
A1  - Lind, Lars
A1  - Willeit, Peter
A1  - Steinmetz, Helmuth
A1  - Desvarieux, Moise
A1  - Ikram, M. Arfan
A1  - Johnsen, Stein Harald
A1  - Schmidt, Caroline
A1  - Willeit, Johann
A1  - Ducimetiere, Pierre
A1  - Price, Jackie F.
A1  - Bergström, Göran
A1  - Kauhanen, Jussi
A1  - Kiechl, Stefan
A1  - Sitzer, Matthias
A1  - Bickel, Horst
A1  - Sacco, Ralph L.
A1  - Hofman, Albert
A1  - Völzke, Henry
A1  - Thompson, Simon G.
T1  - Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium
T2  - European Journal of Preventive Cardiology
N2  - Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.
Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events.
Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.
KW  - risk factors
KW  - CVD biomarker
KW  - risk factor progression
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55391
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-553917
SN  - 2047-4881
SN  - 2047-4873
VL  - 27
IS  - 3
SP  - 234
EP  - 242
PB  - SAGE Publications
CY  - London
ER  -