TY  - JOUR
A1  - Wolters, Miriam C.
A1  - Schmetzer, Julia
A1  - Möser, Christine Verena
A1  - Hahnefeld, Lisa Katharina
A1  - Angioni, Carlo
A1  - Thomas, Dominique Jeanette
A1  - Ferreirós Bouzas, Nerea
A1  - Geisslinger, Gerd
A1  - Niederberger, Ellen
T1  - Exercise-induced changes in bioactive lipids might serve as potential predictors of post-exercise hypotension. A pilot study in healthy volunteers
T2  - Cells
N2  - Post-exercise hypotension (PEH) is the phenomenon of lowered blood pressure after a single bout of exercise. Only a fraction of people develops PEH but its occurrence correlates well with long-term effects of sports on blood pressure. Therefore, PEH has been suggested as a suitable predictor for the effectivity of exercise as therapy in hypertension. Local vascular bioactive lipids might play a potential role in this context. We performed a cross-over clinical pilot study with 18 healthy volunteers to investigate the occurrence of PEH after a single short-term endurance exercise. Furthermore, we investigated the plasma lipid profile with focus on arachidonic acid (AA)-derived metabolites as potential biomarkers of PEH. A single bout of ergometer cycling induced a significant PEH in healthy volunteers with the expected high inter-individual variability. Targeted lipid spectrum analysis revealed significant upregulation of several lipids in the direct post-exercise phase. Among these changes, only 15- hydroxyeicosatetranoic acid (HETE) correlated significantly with the extent of PEH but in an AA-independent manner, suggesting that 15-HETE might act as specific PEH-marker. Our data indicate that specific lipid modulation might facilitate the identification of patients who will benefit from exercise activity in hypertension therapy. However, larger trials including hypertonic patients are necessary to verify the clinical value of this hypothesis.
KW  - bioactive lipids
KW  - exercise
KW  - blood pressure
KW  - post-exercise hypotension
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56128
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-561282
SN  - 2073-4409
N1  - © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
VL  - 9
IS  - 9, art. 2111
SP  - 1
EP  - 17
PB  - MDPI
CY  - Basel
ER  -