TY  - JOUR
A1  - Niederer, Daniel
A1  - Engel, Tilman
A1  - Vogt, Lutz
A1  - Arampatzis, Adamantios
A1  - Banzer, Winfried
A1  - Beck, Heidrun
A1  - Moreno Catalá, María
A1  - Brenner-Fliesser, Michael
A1  - Güthoff, Claas
A1  - Haag, Thore
A1  - Hönning, Alexander
A1  - Pfeifer, Ann-Christin
A1  - Platen, Petra
A1  - Schiltenwolf, Marcus
A1  - Schneider, Christian
A1  - Trompeter, Katharina
A1  - Wippert, Pia-Maria
A1  - Mayer, Frank
T1  - Motor control stabilisation exercise for non-specific low back pain patients : a prospective meta-analysis with multilevel meta-regressions on intervention effects
T2  - Journal of Clinical Medicine
N2  - Low-to-moderate quality meta-analytic evidence shows that motor control stabilisation exercise (MCE) is an effective treatment of non-specific low back pain. A possible approach to overcome the weaknesses of traditional meta-analyses would be that of a prospective meta-analyses. The aim of the present analysis was to generate high-quality evidence to support the view that motor control stabilisation exercises (MCE) lead to a reduction in pain intensity and disability in non-specific low back pain patients when compared to a control group. In this prospective meta-analysis and sensitivity multilevel meta-regression within the MiSpEx-Network, 18 randomized controlled study arms were included. Participants with non-specific low back pain were allocated to an intervention (individualized MCE, 12 weeks) or a control group (no additive exercise intervention). From each study site/arm, outcomes at baseline, 3 weeks, 12 weeks, and 6 months were pooled. The outcomes were current pain (NRS or VAS, 11 points scale), characteristic pain intensity, and subjective disability. A random effects meta-analysis model for continuous outcomes to display standardized mean differences between intervention and control was performed, followed by sensitivity multilevel meta-regressions. Overall, 2391 patients were randomized; 1976 (3 weeks, short-term), 1740 (12 weeks, intermediate), and 1560 (6 months, sustainability) participants were included in the meta-analyses. In the short-term, intermediate and sustainability, moderate-to-high quality evidence indicated that MCE has a larger effect on current pain (SMD = −0.15, −0.15, −0.19), pain intensity (SMD = −0.19, −0.26, −0.26) and disability (SMD = −0.15, −0.27, −0.25) compared with no exercise intervention. Low-quality evidence suggested that those patients with comparably intermediate current pain and older patients may profit the most from MCE. Motor control stabilisation exercise is an effective treatment for non-specific low back pain. Sub-clinical intermediate pain and middle-aged patients may profit the most from this intervention.
KW  - motor control exercise
KW  - stabilization
KW  - chronic low back pain
KW  - unspecific low back pain
KW  - exercise
KW  - lumbago
KW  - lumbalgia
KW  - meta-analysis
KW  - nonspecific
KW  - LBP
KW  - sensorimotor
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56221
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-562210
SN  - 2077-0383
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 9
IS  - 9, art. 3058
SP  - 1
EP  - 19
PB  - MDPI
CY  - Basel
ER  -