TY  - JOUR
A1  - Hernandez Sampere, Lisa
A1  - Vermehren, Johannes
A1  - Mücke, Victoria Therese
A1  - Graf, Christiana
A1  - Peiffer, Kai-Henrik
A1  - Dultz, Georg
A1  - Zeuzem, Stefan
A1  - Waidmann, Oliver
A1  - Filmann, Natalie
A1  - Bojunga, Jörg
A1  - Sarrazin, Christoph
A1  - Friedrich-Rust, Mireen
A1  - Mücke, Marcus Maximilian
T1  - Point shear‐wave elastography using acoustic radiation force impulse imaging for the prediction of liver‐related events in patients with chronic viral hepatitis
T2  - Hepatology communications
N2  - Chronic viral hepatitis is associated with substantial morbidity and mortality worldwide. The aim of our study was to assess the ability of point shear‐wave elastography (pSWE) using acoustic radiation force impulse imaging for the prediction of the following liver‐related events (LREs): new diagnosis of HCC, liver transplantation, or liver‐related death (hepatic decompensation was not included as an LRE). pSWE was performed at study inclusion and compared with liver histology, transient elastography (TE), and serologic biomarkers (aspartate aminotransferase to platelet ratio index, Fibrosis‐4, FibroTest). The performance of pSWE and TE to predict LREs was assessed by calculating the area under the receiver operating characteristic curve and a Cox proportional‐hazards regression model. A total of 254 patients with a median follow‐up of 78 months were included in the study. LRE occurred in 28 patients (11%) during follow‐up. In both patients with hepatitis B virus and hepatitis C virus (HCV), pSWE showed significant correlations with noninvasive tests and TE, and median pSWE and TE values were significantly different between patients with LREs and patients without LREs (both P < 0.0001). In patients with HCV, the area under the receiver operating characteristic curve for pSWE and TE to predict LREs were comparable: 0.859 (95% confidence interval [CI], 0.747‐0.969) and 0.852 (95% CI, 0.737‐0.967) (P = 0.93). In Cox regression analysis, pSWE independently predicted LREs in all patients with HCV (hazard ratio, 17.9; 95% CI, 5.21‐61‐17; P < 0.0001) and those who later received direct‐acting antiviral therapy (hazard ratio, 17.11; 95% CI, 3.88‐75.55; P = 0.0002). Conclusion: Our study shows good comparability between pSWE and TE. pSWE is a promising tool for the prediction of LREs in patients with viral hepatitis, particularly those with chronic HCV. Further studies are needed to confirm our data and assess their prognostic value in other liver diseases.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56948
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-569488
SN  - 2471-254X
VL  - 2020
PB  - Wiley
CY  - Hoboken, NJ
ER  -