TY  - JOUR
A1  - Gebel, Jakob
A1  - Tuppi, Marcel
A1  - Sänger, Nicole
A1  - Schumacher, Björn
A1  - Dötsch, Volker
T1  - DNA damaged induced cell death in oocytes
T2  - Molecules
N2  - The production of haploid gametes through meiosis is central to the principle of sexual reproduction. The genetic diversity is further enhanced by exchange of genetic material between homologous chromosomes by the crossover mechanism. This mechanism not only requires correct pairing of homologous chromosomes but also efficient repair of the induced DNA double-strand breaks. Oocytes have evolved a unique quality control system that eliminates cells if chromosomes do not correctly align or if DNA repair is not possible. Central to this monitoring system that is conserved from nematodes and fruit fly to humans is the p53 protein family, and in vertebrates in particular p63. In mammals, oocytes are stored for a long time in the prophase of meiosis I which, in humans, can last more than 50 years. During the entire time of this arrest phase, the DNA damage checkpoint remains active. The treatment of female cancer patients with DNA damaging irradiation or chemotherapeutics activates this checkpoint and results in elimination of the oocyte pool causing premature menopause and infertility. Here, we review the molecular mechanisms of this quality control system and discuss potential therapeutic intervention for the preservation of the oocyte pool during chemotherapy.
KW  - p63
KW  - p73
KW  - p53 family
KW  - CEP-1
KW  - tetramerization
KW  - transcriptional activity
KW  - oocyte death
KW  - development
KW  - quality control
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57419
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-574196
SN  - 1420-3049
VL  - 25
IS  - 23, Article 5714
PB  - MDPI
CY  - Basel
ER  -