TY  - JOUR
A1  - Breitung, Sven Thomas
A1  - Lopez, Jakob J.
A1  - Dürner, Gerd
A1  - Glaubitz, Clemens
A1  - Göbel, Michael
A1  - Suhartono, Marcel
T1  - A practical synthesis of the 13C/15N-labelled tripeptide N-formyl-Met-Leu-Phe, useful as a reference in solid-state NMR spectroscopy
T2  - Beilstein journal of organic chemistry
N2  - A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully 13C/15N-labelled tripeptide 1 could be isolated in a typical batch. This peptide can be easily crystallised and is therefore well suited as a standard sample for setting up solid-state NMR experiments.
KW  - Fmoc solid phase peptide synthesis
KW  - formylation
KW  - f-MLF
KW  - magic-angle spinning
KW  - Wang resin
Y1  - 2008
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6010
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-60239
SN  - 1860-5397
N1  - This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 4
IS  - 35
SP  - 1
EP  - 4
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  -