TY  - JOUR
A1  - Lapa, Sriramya
A1  - Claus, Inga
A1  - Reitz, Sarah
A1  - Quick-Weller, Johanna
A1  - Sauer, Sonja
A1  - Colbow, Sigrid
A1  - Nasari, Christiane
A1  - Dziewas, Rainer
A1  - Kang, Jun-Suk
A1  - Baudrexel, Simon
A1  - Warnecke, Tobias
T1  - Effect of thalamic deep brain stimulation on swallowing in patients with essential tremor
T2  - Annals of Clinical and Translational Neurology
N2  - Objective: Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is a mainstay treatment for severe and drug-refractory essential tremor (ET). Although stimulation-induced dysarthria has been extensively described, possible impairment of swallowing has not been systematically investigated yet. Methods: Twelve patients with ET and bilateral VIM-DBS with self-reported dysphagia after VIM-DBS were included. Swallowing function was assessed clinically and using by flexible endoscopic evaluation of swallowing in the stim-ON and in the stim-OFF condition. Presence, severity, and improvement of dysphagia were recorded. Results: During stim-ON, the presence of dysphagia could be objectified in all patients, 42% showing mild, 42% moderate, and 16 % severe dysphagia. During stim-OFF, all patients experienced a statistically significant improvement of swallowing function. Interpretation: VIM-DBS may have an impact on swallowing physiology in ET-patients. Further studies to elucidate the prevalence and underlying pathophysiological mechanisms are warranted.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63943
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-639438
SN  - 2328-9503
VL  - 7
IS  - 7
SP  - 1174
EP  - 1180
PB  - Wiley
CY  - Chichester [u.a.]
ER  -