TY  - JOUR
A1  - Brune, Verena
A1  - Tiacci, Enrico
A1  - Pfeil, Ines
A1  - Döring, Claudia
A1  - Eckerle, Susan
A1  - van Noesel, Carel J. M.
A1  - Klapper, Wolfram
A1  - Falini, Brunangelo
A1  - Heydebreck, Anja von
A1  - Metzler, Dirk
A1  - Bräuninger, Andreas
A1  - Hansmann, Martin-Leo
A1  - Küppers, Ralf
T1  - Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis
T2  - The Journal of Experimental Medicine
N2  - The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H) cells, which are dispersed in an abundant nonneoplastic cellular microenvironment. We performed a genome-wide expression study of microdissected L&H lymphoma cells in comparison to normal and other malignant B cells that indicated a relationship of L&H cells to and/or that they originate from germinal center B cells at the transition to memory B cells. L&H cells show a surprisingly high similarity to the tumor cells of T cell–rich B cell lymphoma and classical Hodgkin lymphoma, a partial loss of their B cell phenotype, and deregulation of many apoptosis regulators and putative oncogenes. Importantly, L&H cells are characterized by constitutive nuclear factor {kappa}B activity and aberrant extracellular signal-regulated kinase signaling. Thus, these findings shed new light on the nature of L&H cells, reveal several novel pathogenetic mechanisms in NLPHL, and may help in differential diagnosis and lead to novel therapeutic strategies.
Y1  - 2008
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6911
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-69848
N1  - © 2008 Brune et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
VL  - 205
IS  - 10
SP  - 2251
EP  - 2268
ER  -