TY  - JOUR
A1  - Rabl, Regina
A1  - Soubannier, Vincent
A1  - Scholz, Roland
A1  - Vogel, Frank
A1  - Mendl, Nadine
A1  - Vasiljev-Neumeyer, Andreja
A1  - Körner, Christian
A1  - Jagasia, Ravi
A1  - Keil, Thomas
A1  - Baumeister, Wolfgang
A1  - Cyrklaff, Marek
A1  - Neupert, Walter
A1  - Reichert, Andreas
T1  - Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g
T2  - The Journal of Cell Biology
N2  - Crista junctions (CJs) are important for mitochondrial organization and function, but the molecular basis of their formation and architecture is obscure. We have identified and characterized a mitochondrial membrane protein in yeast, Fcj1 (formation of CJ protein 1), which is specifically enriched in CJs. Cells lacking Fcj1 lack CJs, exhibit concentric stacks of inner membrane in the mitochondrial matrix, and show increased levels of F1FO–ATP synthase (F1FO) supercomplexes. Overexpression of Fcj1 leads to increased CJ formation, branching of cristae, enlargement of CJ diameter, and reduced levels of F1FO supercomplexes. Impairment of F1FO oligomer formation by deletion of its subunits e/g (Su e/g) causes CJ diameter enlargement and reduction of cristae tip numbers and promotes cristae branching. Fcj1 and Su e/g genetically interact. We propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F1FO oligomeric state, thereby controlling membrane curvature of cristae to generate CJs and cristae tips.
Y1  - 2009
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/7335
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-58684
N1  - © 2009 Rabl et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
VL  - 185
IS  - 6
SP  - 1047
EP  - 1063
ER  -