TY  - JOUR
A1  - Anney, Richard
A1  - Klei, Lambertus
A1  - Pinto, Dalila
A1  - Regan, Regina
A1  - Conroy, Judith
A1  - Magalhães, Tiago R.
A1  - Correia, Catarina
A1  - Abrahams, Brett S.
A1  - Sykes, Nuala
A1  - Pagnamenta, Alistair T.
A1  - Almeida, Joana
A1  - Bacchelli, Elena
A1  - Bailey, Anthony J.
A1  - Baird, Gillian
A1  - Battaglia, Agatino
A1  - Berney, Tom
A1  - Bolshakova, Nadia
A1  - Bölte, Sven
A1  - Bolton, Patrick F.
A1  - Bourgeron, Thomas
A1  - Brennan, Sean
A1  - Brian, Jessica
A1  - Carson, Andrew R.
A1  - Casallo, Guillermo
A1  - Casey, Jillian
A1  - Chu, Su H.
A1  - Cochrane, Lynne
A1  - Corsello, Christina
A1  - Crawford, Emily L.
A1  - Crossett, Andrew
A1  - Dawson, Geraldine
A1  - Jonge, Maretha de
A1  - Delorme, Richard
A1  - Drmic, Irene
A1  - Duketis, Eftichia
A1  - Duque, Frederico
A1  - Estes, Annette
A1  - Farrar, Penny
A1  - Fernandez, Bridget A.
A1  - Folstein, Susan E.
A1  - Fombonne, Eric
A1  - Freitag, Christine M.
A1  - Gilbert, John
A1  - Gillberg, Christopher
A1  - Glessner, Joseph T.
A1  - Goldberg, Jeremy
A1  - Green, Jonathan
A1  - Guter, Stephen J.
A1  - Hakonarson, Hakon
A1  - Heron, Elizabeth A.
A1  - Hill, Matthew
A1  - Holt, Richard
A1  - Howe, Jennifer L.
A1  - Hughes, Gillian
A1  - Hus, Vanessa
A1  - Igliozzi, Roberta
A1  - Kim, Cecilia
A1  - Klauck, Sabine M.
A1  - Kolevzon, Alexander
A1  - Korvatska, Olena
A1  - Kustanovich, Vlad
A1  - Lajonchere, Clara M.
A1  - Lamb, Janine A.
A1  - Laskawiec, Magdalena
A1  - Leboyer, Marion
A1  - Le Couteur, Ann
A1  - Leventhal, Bennett L.
A1  - Lionel, Anath C.
A1  - Liu, Xiao-Qing
A1  - Lord, Catherine
A1  - Lotspeich, Linda
A1  - Lund, Sabata C.
A1  - Maestrini, Elena
A1  - Mahoney, William
A1  - Mantoulan, Carine
A1  - Marshall, Christian R.
A1  - McConachie, Helen
A1  - McDougle, Christopher J.
A1  - McGrath, Jane
A1  - McMahon, William M.
A1  - Melhem, Nadine M.
A1  - Merikangas, Alison
A1  - Migita, Ohsuke
A1  - Minshew, Nancy J.
A1  - Mirza, Ghazala K.
A1  - Munson, Jeff
A1  - Nelson, Stanley F.
A1  - Noakes, Carolyn
A1  - Noor, Abdul
A1  - Nygren, Gudrun
A1  - Oliveira, Guiomar
A1  - Papanikolaou, Katerina
A1  - Parr, Jeremy R.
A1  - Parrini, Barbara
A1  - Paton, Tara
A1  - Pickles, Andrew
A1  - Piven, Joseph
A1  - Posey, David J.
A1  - Poustka, Annemarie
A1  - Poustka, Fritz
A1  - Prasad, Aparna
A1  - Ragoussis, Jiannis
A1  - Renshaw, Katy
A1  - Rickaby, Jessica
A1  - Roberts, Wendy
A1  - Roeder, Kathryn
A1  - Roge, Bernadette
A1  - Rutter, Michael L.
A1  - Bierut, Laura Jean
A1  - Rice, John P.
A1  - Salt, Jeff
A1  - Sansom, Katherine
A1  - Sato, Daisuke
A1  - Segurado, Ricardo
A1  - Senman, Lili
A1  - Shah, Naisha
A1  - Sheffield, Val C.
A1  - Soorya, Latha
A1  - Sousa, Inês
A1  - Stoppioni, Vera
A1  - Strawbridge, Christina
A1  - Tancredi, Raffaella
A1  - Tansey, Katherine
A1  - Thiruvahindrapduram, Bhooma
A1  - Thompson, Ann P.
A1  - Thomson, Susanne
A1  - Tryfon, Ana
A1  - Tsiantis, John
A1  - Engeland, Herman van
A1  - Vincent, John B.
A1  - Volkmar, Fred
A1  - Wallace, Simon
A1  - Wang, Kai
A1  - Wang, Zhouzhi
A1  - Wassink, Thomas H.
A1  - Wing, Kirsty
A1  - Wittemeyer, Kerstin
A1  - Wood, Shawn
A1  - Yaspan, Brian L.
A1  - Zurawiecki, Danielle
A1  - Zwaigenbaum, Lonnie
A1  - Betancur, Catalina
A1  - Buxbaum, Joseph D.
A1  - Cantor, Rita M.
A1  - Cook, Edwin H.
A1  - Coon, Hilary
A1  - Cuccaro, Michael L.
A1  - Gallagher, Louise
A1  - Geschwind, Daniel H.
A1  - Gill, Michael
A1  - Haines, Jonathan L.
A1  - Miller, Judith
A1  - Monaco, Anthony P.
A1  - Nurnberger, John I.
A1  - Paterson, Andrew D.
A1  - Pericak-Vance, Margaret Ann
A1  - Schellenberg, Gerard D.
A1  - Scherer, Stephen W.
A1  - Sutcliffe, James S.
A1  - Szatmari, Peter
A1  - Vicente, Astrid M.
A1  - Vieland, Veronica J.
A1  - Wijsman, Ellen M.
A1  - Devlin, Bernie
A1  - Ennis, Sean
A1  - Hallmayer, Joachim
T1  - A genome-wide scan for common alleles affecting risk for autism
T2  - Human molecular genetics
N2  - Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
KW  - alleles
KW  - phenotype
KW  - autistic disorder
KW  - genes
KW  - genome
KW  - genotype
KW  - single nucleotide polymorphism
KW  - genetics
KW  - autism spectrum disorder
KW  - genotype determination
KW  - copy number polymorphism
Y1  - 2010
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/8025
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-80252
SN  - 1460-2083
SN  - 0964-6906
N1  - © The Author 2010. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 19
IS  - 20
SP  - 4072
EP  - 4082
PB  - Oxford Univ. Press
CY  - Oxford
ER  -