TY  - JOUR
A1  - Sarode, Poonam  Ashwin Kumar
A1  - Schaefer, Martina Barbara
A1  - Grimminger, Friedrich
A1  - Seeger, Werner
A1  - Savai, Rajkumar
T1  - Macrophage and tumor cell cross-talk is fundamental for lung tumor progression: we need to talk
T2  - Frontiers in oncology
N2  - Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity, and resistance in lung cancer patients. Accumulating evidence forecasts that the crosstalk between tumor and immune cells takes center stage in cancer development by modulating tumor malignancy, immune cell infiltration, and immune evasion in the tumor microenvironment (TME). Cytokines and chemokines secreted by this crosstalk play a major role in cancer development, progression, and therapeutic management. An increased infiltration of Tumor-associated macrophages (TAMs) was observed in most of the human cancers, including lung cancer. In this review, we emphasize the role of cytokines and chemokines in TAM-tumor cell crosstalk in the lung TME. Given the role of cytokines and chemokines in immunomodulation, we propose that TAM-derived cytokines and chemokines govern the cancer-promoting immune responses in the TME and offer a new immunotherapeutic option for lung cancer treatment.
KW  - lung cancer
KW  - tumor microenvironment
KW  - tumor-associated macrophages
KW  - cytokines
KW  - chemokines
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54478
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-544782
N1  - Copyright © 2020 Sarode, Schaefer, Grimminger, Seeger and Savai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 10
IS  - 324
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -