TY  - JOUR
A1  - Schindler, Cora Rebecca
A1  - Lustenberger, Thomas
A1  - Woschek, Mathias
A1  - Störmann, Philipp
A1  - Henrich, Dirk
A1  - Radermacher, Peter
A1  - Marzi, Ingo
T1  - Severe traumatic brain injury (TBI) modulates the kinetic profile of the inflammatory response of markers for neuronal damage
T2  - Journal of Clinical Medicine
N2  - The inflammatory response plays an important role in the pathophysiology of multiple injuries. This study examines the effects of severe trauma and inflammatory response on markers of neuronal damage. A retrospective analysis of prospectively collected data in 445 trauma patients (Injury Severity Score (ISS) ≥ 16) is provided. Levels of neuronal biomarkers (calcium-binding Protein B (S100b), Enolase2 (NSE), glial fibrillary acidic protein (GFAP)) and Interleukins (IL-6, IL-10) in severely injured patients (with polytrauma (PT)) without traumatic brain injury (TBI) or with severe TBI (PT+TBI) and patients with isolated TBI (isTBI) were measured upon arrival until day 5. S100b, NSE, GFAP levels showed a time-dependent decrease in all cohorts. Their expression was higher after multiple injuries (p = 0.038) comparing isTBI. Positive correlation of marker level after concomitant TBI and isTBI (p = 0.001) was noted, while marker expression after PT appears to be independent. Highest levels of IL-6 and -10 were associated to PT und lowest to isTBI (p < 0.001). In all groups pro-inflammatory response (IL-6/-10 ratio) peaked on day 2 and at a lower level on day 4. Severe TBI modulates kinetic profile of inflammatory response by reducing interleukin expression following trauma. Potential markers for neuronal damage have a limited diagnostic value after severe trauma because undifferentiated increase.
KW  - multiple trauma
KW  - traumatic brain injury (TBI)
KW  - risk prediction
KW  - biomarker
KW  - IL-6
KW  - IL-10
KW  - posttraumatic inflammation
KW  - S100b
KW  - NSE
KW  - GFAP
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55576
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-555762
SN  - 2077-0383
VL  - 9
IS  - (6), article 1667
PB  - MDPI
CY  - Basel
ER  -