TY  - JOUR
A1  - Scharf, Sonja
A1  - Ackermann, Jörg
A1  - Wurzel, Patrick
A1  - Hansmann, Martin-Leo
A1  - Koch, Ina
T1  - Computational systems biology of cellular processes in the human lymph node
T2  - Current opinion in systems biology
N2  - The human immune system is determined by the functionality of the human lymph node. With the use of high-throughput techniques in clinical diagnostics, a large number of data is currently collected. The new data on the spatiotemporal organization of cells offers new possibilities to build a mathematical model of the human lymph node - a virtual lymph node. The virtual lymph node can be applied to simulate drug responses and may be used in clinical diagnosis. Here, we review mathematical models of the human lymph node from the viewpoint of cellular processes. Starting with classical methods, such as systems of differential equations, we discuss the values of different levels of abstraction and methods in the range from artificial intelligence techniques formalism.
KW  - lymph node
KW  - immune response
KW  - modeling
KW  - Petri net
KW  - agent-based modeling
KW  - ordinary differential equation
KW  - partial differential equation
KW  - artificial intelligence
Y1  - 2024
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/85631
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-856312
SN  - 2452-3100
VL  - 2024
IS  - Journal Pre-proof, 100518
PB  - Elsevier
CY  - Amsterdam
ER  -