TY  - JOUR
A1  - Fulda, Simone
T1  - Autophagy in cancer therapy
T2  - Frontiers in oncology
N2  - Autophagy represents a catabolic program involved in the degradation of cellular components via lysosomes. It serves to mitigate cellular stress and to provide metabolic precursors especially upon starvation. Thereby, autophagy can support the survival of cancer cells. In addition, there is now convincing evidence showing that under certain conditions autophagy can also foster cell death. This dual function of autophagy is also relevant upon anticancer treatment, as many chemotherapeutic agents engage autophagy. A better understanding of the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells will be instrumental to selectively interfere with this cellular program in order to increase the cancer cell’s response to cytotoxic drugs. This review illustrates how anticancer drug-induced autophagy is involved in mediating cell death.
KW  - autophagy
KW  - cell death
KW  - cancer
KW  - autophagic cell death
KW  - cancer therapy
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54299
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-542990
SN  - 2234-943X
N1  - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). http://creativecommons.org/licenses/by/4.0/
VL  - 7
IS  - article 128
SP  - 1
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -