TY  - JOUR
A1  - Puller, Christian
A1  - Arbogast, Patrick
A1  - Keeley, Patrick W.
A1  - Reese, Benjamin E.
A1  - Haverkamp, Silke
T1  - Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors
T2  - PLoS one
N2  - Retinal OFF bipolar cells show distinct connectivity patterns with photoreceptors in the wild-type mouse retina. Some types are cone-specific while others penetrate further through the outer plexiform layer (OPL) to contact rods in addition to cones. To explore dendritic stratification of OFF bipolar cells in the absence of rods, we made use of the ‘cone-full’ Nrl-/- mouse retina in which all photoreceptor precursor cells commit to a cone fate including those which would have become rods in wild-type retinas. The dendritic distribution of OFF bipolar cell types was investigated by confocal and electron microscopic imaging of immunolabeled tissue sections. The cells’ dendrites formed basal contacts with cone terminals and expressed the corresponding glutamate receptor subunits at those sites, indicating putative synapses. All of the four analyzed cell populations showed distinctive patterns of vertical dendritic invasion through the OPL. This disparate behavior of dendritic extension in an environment containing only cone terminals demonstrates type-dependent specificity for dendritic outgrowth in OFF bipolar cells: rod terminals are not required for inducing dendritic extension into distal areas of the OPL.
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43147
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-431474
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336283
SN  - 1932-6203
N1  - Copyright: © 2017 Puller et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 12
IS  - (3): e0173455
SP  - 1
EP  - 11
PB  - PLoS
CY  - Lawrence, Kan.
ER  -