TY  - JOUR
A1  - Wenners, Antonia Sophie
A1  - Mehta, Keyur
A1  - Loibl, Sibylle
A1  - Park, Hyerim
A1  - Müller, Berit
A1  - Arnold, Norbert
A1  - Hamann, Sigrid
A1  - Weimer, Joerg
A1  - Ataseven, Beyhan
A1  - Darb-Esfahani, Silvia
A1  - Schem, Christian
A1  - Mundhenke, Christoph
A1  - Khandan, Fariba
A1  - Thomssen, Christoph
A1  - Jonat, Walter
A1  - Holzhausen, Hans-Jürgen
A1  - Minckwitz, Gunter von
A1  - Denkert, Carsten Michael
A1  - Bauer, Maret
T1  - Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer
T2  - PLoS One
N2  - In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis. In neoadjuvant chemotherapy (NACT) pathological complete response (pCR) is a predictor for outcome. The aim of this study was to evaluate NGAL as a predictor of response to NACT and to validate NGAL as a prognostic factor for clinical outcome in patients with primary BC. Immunohistochemistry was performed on tissue microarrays from 652 core biopsies from BC patients, who underwent NACT in the GeparTrio trial. NGAL expression and intensity was evaluated separately. NGAL was detected in 42.2% of the breast carcinomas in the cytoplasm. NGAL expression correlated with negative hormone receptor (HR) status, but not with other baseline parameters. NGAL expression did not correlate with pCR in the full population, however, NGAL expression and staining intensity were significantly associated with higher pCR rates in patients with positive HR status. In addition, strong NGAL expression correlated with higher pCR rates in node negative patients, patients with histological grade 1 or 2 tumors and a tumor size <40 mm. In univariate survival analysis, positive NGAL expression and strong staining intensity correlated with decreased disease-free survival (DFS) in the entire cohort and different subgroups, including HR positive patients. Similar correlations were found for intense staining and decreased overall survival (OS). In multivariate analysis, NGAL expression remained an independent prognostic factor for DFS. The results show that in low-risk subgroups, NGAL was found to be a predictive marker for pCR after NACT. Furthermore, NGAL could be validated as an independent prognostic factor for decreased DFS in primary human BC.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26750
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-267504
SN  - 1932-6203
VL  - 7
IS  - (10):e45826
PB  - PLoS
CY  - Lawrence, Kan.
ER  -