TY  - JOUR
A1  - Huckins, Laura M.
A1  - Hatzikotoulas, Konstantinos
A1  - Southam, Lorraine
A1  - Thornton, Laura M.
A1  - Steinberg, Julia
A1  - Mckay Aguilera, Fernando Riveros
A1  - Treasure, Janet
A1  - Schmidt, Ulrike
A1  - Gunasinghe, Cerisse
A1  - Romero, Anibal
A1  - Curtis, Charles
A1  - Rhodes, Daniel
A1  - Moens, Julie
A1  - Kalsi, Gursharan
A1  - Dempster, David
A1  - Leung, Rufina
A1  - Keohane, Aoife
A1  - Burghardt, Roland
A1  - Ehrlich, Stefan
A1  - Hebebrand, Johannes
A1  - Hinney, Anke
A1  - Ludolph, Anja
A1  - Walton, Esther
A1  - Deloukas, Panos
A1  - Hofman, Albert
A1  - Palotie, Aarno
A1  - Palta, Priit
A1  - Rooij, Frank J. A. van
A1  - Stirrups, Kathleen
A1  - Adan, Roger
A1  - Boni, Claudette
A1  - Cone, Roger
A1  - Dedoussis, George
A1  - Furth, Eric van
A1  - Gonidakis, Fragiskos
A1  - Gorwood, Philip
A1  - Hudson, James I.
A1  - Kaprio, Jaakko
A1  - Kas, Martien
A1  - Keski-Rahkonen, Anna
A1  - Kiezebrink, Kirsty
A1  - Knudsen, Gun Peggy
A1  - Slof-Op ‘t Landt, Margarita C. T.
A1  - Maj, Mario
A1  - Monteleone, Alessio Maria
A1  - Monteleone, Palmiero
A1  - Raevuori, Anu
A1  - Reichborn-Kjennerud, Ted
A1  - Tozzi, Federica
A1  - Tsitsika, Artemis
A1  - Elburg, Annemarie van
A1  - Collier, David A.
A1  - Sullivan, Patrick F.
A1  - Breen, Gerome
A1  - Bulik, Cynthia M.
A1  - Zeggini, Eleftheria
T1  - Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
T2  - Molecular psychiatry
N2  - Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
KW  - Genetics
KW  - Molecular biology
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50362
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-503627
SN  - 1476-5578
SN  - 1359-4184
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
N1  - Correction erschienen in: Molecular psychiatry, 23.2018, Nr. 9, S. 1969, doi:10.1038/mp.2017.202
VL  - 23
IS  - 5
SP  - 1169
EP  - 1180
PB  - Macmillan
CY  - London
ER  -