TY  - JOUR
A1  - Lévesque, C. André
A1  - Brouwer, Henk
A1  - Cano, Liliana
A1  - Hamilton, John P.
A1  - Holt, Carson
A1  - Huitema, Edgar
A1  - Raffaele, Sylvain
A1  - Robideau, Gregg P.
A1  - Thines, Marco
A1  - Win, Joe
A1  - Zerillo, Marcelo M.
A1  - Beakes, Gordon W.
A1  - Boore, Jeffrey L.
A1  - Busam, Dana
A1  - Dumas, Bernard
A1  - Ferriera, Steve
A1  - Fürstenberg, Susan
A1  - Gachon, Claire M. M.
A1  - Gaulin, Elodie
A1  - Govers, Francine
A1  - Grenville-Briggs, Laura
A1  - Horner, Neil
A1  - Hostetler, Jessica
A1  - Jiang, Rays H. Y.
A1  - Johnson, Justin
A1  - Krajaejun, Theerapong
A1  - Lin, Haining
A1  - Meijer, Harold J. G.
A1  - Moore, Barry
A1  - Morris, Paul
A1  - Phuntmart, Vipaporn
A1  - Puiu, Daniela
A1  - Shetty, Jyoti
A1  - Stajich, Jason E.
A1  - Tripathy, Sucheta
A1  - Wawra, Stephan
A1  - West, Pieter van
A1  - Whitty, Brett R.
A1  - Coutinho, Pedro M.
A1  - Henrissat, Bernard
A1  - Martin, Frank
A1  - Thomas, Paul D.
A1  - Tyler, Brett M.
A1  - Vries, Ronald Peter de
A1  - Kamoun, Sophien
A1  - Yandell, Mark
A1  - Tisserat, Ned
A1  - Buell, C. Robin
T1  - Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire
T2  - Genome biology
N2  - Background: Pythium ultimum (P. ultimum) is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species. Results: The P. ultimum genome (42.8 Mb) encodes 15,290 genes and has extensive sequence similarity and synteny with related Phytophthora species, including the potato blight pathogen Phytophthora infestans. Whole transcriptome sequencing revealed expression of 86% of genes, with detectable differential expression of suites of genes under abiotic stress and in the presence of a host. The predicted proteome includes a large repertoire of proteins involved in plant pathogen interactions although surprisingly, the P. ultimum genome does not encode any classical RXLR effectors and relatively few Crinkler genes in comparison to related phytopathogenic oomycetes. A lower number of enzymes involved in carbohydrate metabolism were present compared to Phytophthora species, with the notable absence of cutinases, suggesting a significant difference in virulence mechanisms between P. ultimum and more host specific oomycete species. Although we observed a high degree of orthology with Phytophthora genomes, there were novel features of the P. ultimum proteome including an expansion of genes involved in proteolysis and genes unique to Pythium. We identified a small gene family of cadherins, proteins involved in cell adhesion, the first report in a genome outside the metazoans. Conclusions: Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae.
Y1  - 2010
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/7915
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-78353
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926784
SN  - 1465-6914
SN  - 1465-6906
N1  - © 2010 Lévesque et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 11
IS  - R73
SP  - 1
EP  - 22
PB  - BioMed Central
CY  - London
ER  -