TY  - JOUR
A1  - Richter, Christian
A1  - Hohmann, Katharina Felicitas
A1  - Toews, Sabrina
A1  - Mathieu, Daniel
A1  - Altınçekiç, Nadide
A1  - Bains, Jasleen Kaur
A1  - Binas, Oliver
A1  - Ceylan, Betül
A1  - Duchardt-Ferner, Elke
A1  - Ferner, Jan
A1  - Fürtig, Boris
A1  - Grün, J. Tassilo
A1  - Hengesbach, Martin
A1  - Hymon, Daniel
A1  - Jonker, Hendrik R. A.
A1  - Knežić, Božana
A1  - Korn, Sophie
A1  - Landgraf, Tom
A1  - Löhr, Frank
A1  - Peter, Stephen A.
A1  - Pyper, Dennis Joshua
A1  - Qureshi, Nusrat
A1  - Schlundt, Andreas
A1  - Schnieders, Robbin
A1  - Stirnal, Elke
A1  - Sudakov, Alexey
A1  - Vögele, Jennifer
A1  - Weigand, Julia
A1  - Wirmer-Bartoschek, Julia
A1  - Witt, Kerstin
A1  - Wöhnert, Jens
A1  - Schwalbe, Harald
A1  - Wacker, Anna
T1  - 1H, 13C and 15N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2
T2  - Biomolecular NMR assignments
N2  - The stem-loop (SL1) is the 5'-terminal structural element within the single-stranded SARS-CoV-2 RNA genome. It is formed by nucleotides 7–33 and consists of two short helical segments interrupted by an asymmetric internal loop. This architecture is conserved among Betacoronaviruses. SL1 is present in genomic SARS-CoV-2 RNA as well as in all subgenomic mRNA species produced by the virus during replication, thus representing a ubiquitous cis-regulatory RNA with potential functions at all stages of the viral life cycle. We present here the 1H, 13C and 15N chemical shift assignment of the 29 nucleotides-RNA construct 5_SL1, which denotes the native 27mer SL1 stabilized by an additional terminal G-C base-pair.
KW  - SARS-CoV-2
KW  - 5'-UTR
KW  - SL1
KW  - Solution NMR spectroscopy
KW  - COVID19-NMR
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63569
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-635695
SN  - 1874-270X
N1  - Open Access funding enabled and organized by Projekt DEAL. Work at the Center for Biomolecular Magnetic Resonance (BMRZ) at the Goethe-University Frankfurt is supported by the state of Hesse. Work in Covid19-nmr was supported by the Goethe Corona Funds, by the IWB-EFRE-programme 20007375 of the state of Hesse, and the DFG in CRC902: “Molecular Principles of RNA-based regulation.” and infrastructure funds (Project Numbers: 277478796, 277479031, 392682309, 452632086, 70653611). K. F. H., B. F., B. K., H. S., and J. T. G. are supported by the DFG in graduate school CLIC (GRK 1986). D. J. P. and H. S. are supported by the DFG in SPP2002. A.W., B. F., O. B., S. K., A. S., M. H., Ju. Wei, Je. Woe. and H. S. are supported by the DFG in CRC902. T. L. and H. S. are supported by the DFG in SPP1879. J. K. B. and H. S. are supported by the DFG in TRR 267, H. R. A. Jonker and H.S. are supported by the DFG in FOR2509. A. S. is funded by the Deutsche Forschungsgemeinschaft through Grant number SCHL2062/2-1 and by the Johanna Quandt Young Academy at Goethe (Grant number 2019/AS01).
VL  - 15
SP  - 467
EP  - 474
PB  - Springer Netherlands
CY  - Dordrecht [u.a.]
ER  -