TY  - JOUR
A1  - Anney, Richard
A1  - Klei, Lambertus
A1  - Pinto, Dalila
A1  - Almeida, Joana
A1  - Bacchelli, Elena
A1  - Baird, Gillian
A1  - Bolshakova, Nadia
A1  - Bölte, Sven
A1  - Bolton, Patrick F.
A1  - Bourgeron, Thomas
A1  - Brennan, Sean
A1  - Brian, Jessica
A1  - Casey, Jillian
A1  - Conroy, Judith
A1  - Correia, Catarina
A1  - Corsello, Christina
A1  - Crawford, Emily L.
A1  - Jonge, Maretha de
A1  - Delorme, Richard
A1  - Duketis, Eftichia
A1  - Duque, Frederico
A1  - Estes, Annette
A1  - Farrar, Penny
A1  - Fernandez, Bridget A.
A1  - Folstein, Susan E.
A1  - Fombonne, Eric
A1  - Gilbert, John
A1  - Gillberg, Christopher
A1  - Glessner, Joseph T.
A1  - Green, Andrew
A1  - Green, Jonathan
A1  - Guter, Stephen J.
A1  - Heron, Elizabeth A.
A1  - Holt, Richard
A1  - Howe, Jennifer L.
A1  - Hughes, Gillian
A1  - Hus, Vanessa
A1  - Igliozzi, Roberta
A1  - Jacob, Suma
A1  - Kenny, Graham P.
A1  - Kim, Cecilia
A1  - Kolevzon, Alexander
A1  - Kustanovich, Vlad
A1  - Lajonchere, Clara M.
A1  - Lamb, Janine A.
A1  - Law-Smith, Miriam
A1  - Leboyer, Marion
A1  - Le Couteur, Ann
A1  - Leventhal, Bennett L.
A1  - Liu, Xiao-Qing
A1  - Lombard, Frances
A1  - Lord, Catherine
A1  - Lotspeich, Linda
A1  - Lotspeich, Linda
A1  - Lund, Sabata C.
A1  - Magalhães, Tiago R.
A1  - Mantoulan, Carine
A1  - McDougle, Christopher J.
A1  - Melhem, Nadine M.
A1  - Merikangas, Alison
A1  - Minshew, Nancy J.
A1  - Mirza, Ghazala K.
A1  - Munson, Jeff
A1  - Noakes, Carolyn
A1  - Nygren, Gudrun
A1  - Papanikolaou, Katerina
A1  - Pagnamenta, Alistair T.
A1  - Parrini, Barbara
A1  - Paton, Tara
A1  - Paton, Tara
A1  - Pickles, Andrew
A1  - Posey, David J.
A1  - Poustka, Fritz
A1  - Ragoussis, Jiannis
A1  - Regan, Regina
A1  - Roberts, Wendy
A1  - Roeder, Kathryn
A1  - Roge, Bernadette
A1  - Rutter, Michael L.
A1  - Schlitt, Sabine
A1  - Shah, Naisha
A1  - Sheffield, Val C.
A1  - Soorya, Latha
A1  - Sousa, Inês
A1  - Stoppioni, Vera
A1  - Sykes, Nuala
A1  - Tancredi, Raffaella
A1  - Thompson, Ann P.
A1  - Thomson, Susanne
A1  - Tryfon, Ana
A1  - Tsiantis, John
A1  - Engeland, Herman van
A1  - Vincent, John B.
A1  - Volkmar, Fred
A1  - Vorstman, JAS
A1  - Wallace, Simon
A1  - Wing, Kirsty
A1  - Wittemeyer, Kerstin
A1  - Wood, Shawn
A1  - Zurawiecki, Danielle
A1  - Zwaigenbaum, Lonnie
A1  - Bailey, Anthony J.
A1  - Battaglia, Agatino
A1  - Cantor, Rita M.
A1  - Coon, Hilary
A1  - Cuccaro, Michael L.
A1  - Dawson, Geraldine
A1  - Ennis, Sean
A1  - Freitag, Christine M.
A1  - Geschwind, Daniel H.
A1  - Haines, Jonathan L.
A1  - Klauck, Sabine M.
A1  - McMahon, William M.
A1  - Maestrini, Elena
A1  - Miller, Judith
A1  - Monaco, Anthony P.
A1  - Nelson, Stanley F.
A1  - Nurnberger, John I.
A1  - Oliveira, Guiomar
A1  - Parr, Jeremy R.
A1  - Pericak-Vance, Margaret Ann
A1  - Piven, Joseph
A1  - Schellenberg, Gerard D.
A1  - Scherer, Stephen W.
A1  - Vicente, Astrid M.
A1  - Wassink, Thomas H.
A1  - Wijsman, Ellen M.
A1  - Betancur, Catalina
A1  - Buxbaum, Joseph D.
A1  - Cook, Edwin H.
A1  - Gallagher, Louise
A1  - Gill, Michael
A1  - Hallmayer, Joachim
A1  - Paterson, Andrew D.
A1  - Sutcliffe, James S.
A1  - Szatmari, Peter
A1  - Vieland, Veronica J.
A1  - Hakonarson, Hakon
A1  - Devlin, Bernie
T1  - Individual common variants exert weak effects on the risk for autism spectrum disorders
T2  - Human molecular genetics : HMG online
N2  - While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28899
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-288990
N1  - © The Author 2012. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 21
IS  - 21
SP  - 4781
EP  - 4792
PB  - Oxford Univ. Press
CY  - Oxford
ER  -