TY  - JOUR
A1  - Rothbauer, Mario
A1  - Bachmann, Barbara E. M.
A1  - Eilenberger, Christoph
A1  - Kratz, Sebastian R. A.
A1  - Spitz, Sarah
A1  - Höll, Gregor
A1  - Ertl, Peter
T1  - A decade of organs-on-a-chip emulating human physiology at the microscale: a critical status report on progress in toxicology and pharmacology
T2  - Micromachines
N2  - Organ-on-a-chip technology has the potential to accelerate pharmaceutical drug development, improve the clinical translation of basic research, and provide personalized intervention strategies. In the last decade, big pharma has engaged in many academic research cooperations to develop organ-on-a-chip systems for future drug discoveries. Although most organ-on-a-chip systems present proof-of-concept studies, miniaturized organ systems still need to demonstrate translational relevance and predictive power in clinical and pharmaceutical settings. This review explores whether microfluidic technology succeeded in paving the way for developing physiologically relevant human in vitro models for pharmacology and toxicology in biomedical research within the last decade. Individual organ-on-a-chip systems are discussed, focusing on relevant applications and highlighting their ability to tackle current challenges in pharmacological research.
KW  - organs-on-a-chip
KW  - body-on-a-chip
KW  - micro-physiological systems
KW  - bioprinting
KW  - lung-on-a-chip
KW  - liver-on-a-chip
KW  - skin-on-a-chip
KW  - kidney-on-a-chip
KW  - heart-on-a-chip
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62130
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621306
SN  - 2072-666X
N1  - The APC was funded by TU Wien University Library for financial support through its Open Access Funding Program.
VL  - 12
IS  - 5, art. 470
SP  - 1
EP  - 54
PB  - MDPI
CY  - Basel
ER  -