TY  - JOUR
A1  - Weil, Andrea
A1  - Luce, Karin
A1  - Dröse, Stefan
A1  - Wittig, Ilka
A1  - Brandt, Ulrich
A1  - Osiewacz, Heinz D.
T1  - Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development
T2  - Cell cycle
N2  - Different molecular pathways involved in maintaining mitochondrial function are of fundamental importance to control cellular homeostasis. Mitochondrial i-AAA protease is part of such a surveillance system, and PaIAP is the putative ortholog in the fungal aging model Podospora anserina. Here, we investigate the role of PaIAP in aging and development. Deletion of the gene encoding PaIAP resulted in a specific phenotype. When incubated at 27°C, spore germination and fruiting body formation are not different from that of the corresponding wild-type strain. Unexpectedly, the lifespan of the deletion strain is strongly increased. In contrast, cultivation at an elevated temperature of 37°C leads to impairments in spore germination and fruiting body formation and to a reduced lifespan. The higher PaIAP abundance in wild-type strains of the fungus grown at elevated temperature and the phenotype of the deletion strain unmasks a temperature-related role of the protein. The protease appears to be part of a molecular system that has evolved to allow survival under changing temperatures, as they characteristically occur in nature.
KW  - Podospora anserina
KW  - aging
KW  - mitochondria
KW  - protein quality control
KW  - temperature
KW  - i-AAA protease
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31495
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-314958
SN  - 1551-4005
SN  - 1538-4101
N1  - © 2011 Landes Bioscience
VL  - 10
IS  - 24
SP  - 4280
EP  - 4290
PB  - Landes Bioscience
CY  - Georgetown, Tex.
ER  -