TY  - JOUR
A1  - Queck, Alexander David Roger
A1  - Thomas, Dominique Jeanette
A1  - Jansen, Christian
A1  - Schreiber, Yannick
A1  - Rüschenbaum, Sabrina
A1  - Praktiknjo, Michael
A1  - Schwarzkopf, Katharina
A1  - Mücke, Marcus Maximilian
A1  - Schierwagen, Robert
A1  - Uschner, Frank Erhard
A1  - Meyer, Carsten
A1  - Clària, Joan
A1  - Zeuzem, Stefan
A1  - Geisslinger, Gerd
A1  - Trebicka, Jonel
A1  - Lange, Christian
T1  - Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis
T2  - PLoS one
N2  - Background: Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated.
Methods: Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study the role of prostanoids in decompensated liver cirrhosis. Here, 89 patients receiving transjugular intrahepatic portosystemic shunt insertion were included in the study, and baseline levels of thromboxane B2, prostaglandin D2 and prostaglandin E2 were measured in the portal and the hepatic vein.
Results: While the hepatic vein contained higher levels of thromboxane B2 than the portal vein, levels of prostaglandin E2 and D2 were higher in the portal vein (all P<0.0001). Baseline concentrations of thromboxane B2 in the portal vein were independently associated with an increase of portal hepatic venous pressure gradient during short term follow-up, as an indirect sign of thrombogenic potential (multivariable P = 0.004). Moreover, severity of liver disease was inversely correlated with portal as well as hepatic vein levels of prostaglandin D2 and E2 (all P<0.0001).
Conclusions: Elevated portal venous thromboxane B2 concentrations are possibly associated with the extent of thrombogenic potential in patients with decompensated liver cirrhosis.
Trial registration: ClinicalTrials.gov identifier: NCT03584204.
KW  - Portal veins
KW  - Cirrhosis
KW  - Veins
KW  - Prostaglandin
KW  - Thromboxane
KW  - Liver diseases
KW  - Platelets
KW  - Thrombosis
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51397
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-513970
SN  - 1932-6203
N1  - Copyright: © 2019 Queck et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 14
IS  - (10): e0222840
SP  - 1
EP  - 12
PB  - PLoS
CY  - Lawrence, Kan.
ER  -