TY  - JOUR
A1  - Keiten-Schmitz, Jan
A1  - Röder, Linda
A1  - Hornstein, Eran
A1  - Müller-McNicoll, Michaela
A1  - Müller, Stefan
T1  - SUMO : glue or solvent for phase-separated ribonucleoprotein complexes and molecular condensates?
T2  - Frontiers in molecular biosciences
N2  - Spatial organization of cellular processes in membranous or membrane-less organelles (MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical pathways. Prime examples of MLOs are the nucleolus, PML nuclear bodies, nuclear splicing speckles or cytosolic stress granules. They all represent distinct sub- cellular structures typically enriched in intrinsically disordered proteins and/or RNA and are formed in a process driven by liquid-liquid phase separation. Several MLOs are critically involved in proteostasis and their formation, disassembly and composition are highly sensitive to proteotoxic insults. Changes in the dynamics of MLOs are a major driver of cell dysfunction and disease. There is growing evidence that post-translational modifications are critically involved in controlling the dynamics and composition of MLOs and recent evidence supports an important role of the ubiquitin-like SUMO system in regulating both the assembly and disassembly of these structures. Here we will review our current understanding of SUMO function in MLO dynamics under both normal and pathological conditions.
KW  - SUMO
KW  - RNF4
KW  - PML
KW  - membrane-less organelles
KW  - nucleolus
KW  - stress granules
KW  - splicing
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61250
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-612507
SN  - 2296-889X
N1  - Work in the Müller lab was funded by DFG collaborative research cebters SFB815 and SFB1177. MM-M and SM are part of the Cluster project ENABLE funded by the State of Hesse. Work in the Hornstein lab is supported by Mondry Family Professorial Chair, RADALA Foundation, Weizmann – Brazil Center for Research on Neurodegeneration and Minerva Foundation with funding from the Federal German Ministry for Education and Research.
VL  - 8
IS  - art. 673038
SP  - 1
EP  - 9
PB  - Frontiers in molecular biosciences
CY  - Lausanne
ER  -