TY  - JOUR
A1  - Rajan, Roopa
A1  - Divya, K. P.
A1  - Kandadai, Rukmini Mridula
A1  - Yadav, Ravi
A1  - Satagopam, Venkata P.
A1  - Satagopam, Venkata P.
A1  - Madhusoodanan, U. K.
A1  - Agarwal, Pankaj
A1  - Kumar, Niraj
A1  - Ferreira, Teresa
A1  - Kumar, Hrishikesh
A1  - Prasad, A. V. Sreeram
A1  - Shetty, Kuldeep
A1  - Mehta, Sahil
A1  - Desai, Soaham
A1  - Kumar, Suresh
A1  - Prashant, L. K.
A1  - Bhatt, Mohit
A1  - Wadia, Pettarusp
A1  - Ramalingam, Sudha
A1  - Wali, G. M.
A1  - Pandey, Sanjay
A1  - Bartusch, Felix
A1  - Hannussek, Maximilian
A1  - Krüger, Jens
A1  - Kumar-Sreelatha, Ashwin
A1  - Grover, Sandeep
A1  - Lichtner, Peter
A1  - Sturm, Marc
A1  - Roeper, Jochen
A1  - Busskamp, Volker
A1  - Chandak, Giriraj R.
A1  - Schwamborn, Jens
A1  - Seth, Pankaj
A1  - Gasser, Thomas
A1  - Rieß, Olaf
A1  - Goyal, Vinay
A1  - Goyal, Vinay
A1  - Pal, Pramod Kumar
A1  - Borgohain, Rupam
A1  - Krüger, Rejko
A1  - Kishore, Asha
A1  - Sharma, Manu
T1  - Genetic architecture of Parkinson's disease in the Indian population: harnessing genetic diversity to address critical gaps in Parkinson's disease research
T2  - Frontiers in neurology
N2  - Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from the discoveries made in familial and/or sporadic forms of PD in the Caucasian population. The transferability and the clinical utility of genetic discoveries to other ethnically diverse populations are unknown. The Indian population has been under-represented in PD research. The Genetic Architecture of PD in India (GAP-India) project aims to develop one of the largest clinical/genomic bio-bank for PD in India. Specifically, GAP-India project aims to: (1) develop a pan-Indian deeply phenotyped clinical repository of Indian PD patients; (2) perform whole-genome sequencing in 500 PD samples to catalog Indian genetic variability and to develop an Indian PD map for the scientific community; (3) perform a genome-wide association study to identify novel loci for PD and (4) develop a user-friendly web-portal to disseminate results for the scientific community. Our “hub-spoke” model follows an integrative approach to develop a pan-Indian outreach to develop a comprehensive cohort for PD research in India. The alignment of standard operating procedures for recruiting patients and collecting biospecimens with international standards ensures harmonization of data/bio-specimen collection at the beginning and also ensures stringent quality control parameters for sample processing. Data sharing and protection policies follow the guidelines established by local and national authorities.We are currently in the recruitment phase targeting recruitment of 10,200 PD patients and 10,200 healthy volunteers by the end of 2020. GAP-India project after its completion will fill a critical gap that exists in PD research and will contribute a comprehensive genetic catalog of the Indian PD population to identify novel targets for PD.
KW  - Parkinson's disease
KW  - genetic diversity
KW  - genome-wide association study
KW  - common genetic variation
KW  - biobank
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54924
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-549246
SN  - 1664-2295
VL  - 11
IS  - 524
SP  - 1
EP  - 11
PB  - Frontiers Media
CY  - Lausanne
ER  -