TY  - JOUR
A1  - Laakmann, Elena
A1  - Witzel, Isabell
A1  - Scriba, Verena
A1  - Grzyska, Ulrich
A1  - Eulenburg, Christine Helene zu
A1  - Burchardi, Nicole
A1  - Hesse, Tobias
A1  - Würschmidt, Florian
A1  - Fehm, Tanja
A1  - Möbus, Volker
A1  - Minckwitz, Gunter von
A1  - Loibl, Sibylle
A1  - Park-Simon, Tjoung-Won
A1  - Müller, Volkmar
T1  - Radiological patterns of brain metastases in breast cancer patients : a subproject of the german brain metastases in breast cancer (BMBC) registry
T2  - International journal of molecular sciences
N2  - Evidence about distribution patterns of brain metastases with regard to breast cancer subtypes and its influence on the prognosis of patients is insufficient. Clinical data, cranial computed tomography (CT) and magnetic resonance imaging (MRI) scans of 300 breast cancer patients with brain metastases (BMs) were collected retrospectively in four centers participating in the Brain Metastases in Breast Cancer Registry (BMBC) in Germany. Patients with positive estrogen (ER), progesterone (PR), or human epidermal growth factor receptor 2 (HER2) statuses, had a significantly lower number of BMs at diagnosis. Concerning the treatment mode, HER2-positive patients treated with trastuzumab before the diagnosis of BMs showed a lower number of intracranial metastases (p < 0.001). Patients with a HER2-positive tumor-subtype developed cerebellar metastases more often compared with HER2-negative patients (59.8% vs. 44.5%, p = 0.021), whereas patients with triple-negative primary tumors had leptomeningeal disease more often (31.4% vs. 18.3%, p = 0.038). The localization of Brain metastases (BMs) was associated with prognosis: patients with leptomeningeal disease had shorter survival compared with patients without signs of leptomeningeal disease (median survival 3 vs. 5 months, p = 0.025). A shorter survival could also be observed in the patients with metastases in the occipital lobe (median survival 3 vs. 5 months, p = 0.012). Our findings suggest a different tumor cell homing to different brain regions depending on subtype and treatment. View Full-Text
KW  - radiological
KW  - pattern
KW  - brain metastases
KW  - breast cancer
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43123
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-431239
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085648
SN  - 1422-0067
SN  - 1661-6596
N1  - © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
VL  - 17
IS  - (10), 1615
SP  - 1
EP  - 8
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -