TY  - JOUR
A1  - Poorthuis, Rogier B.
A1  - Muhammad, Karzan
A1  - Wang, Mantian
A1  - Verhoog, Matthijs B.
A1  - Junek, Stephan
A1  - Wrana, Anne
A1  - Mansvelder, Huibert D.
A1  - Letzkus, Johannes J.
T1  - Rapid neuromodulation of ayer 1 interneurons in human neocortex
T2  - Cell reports
N2  - Inhibitory interneurons govern virtually all computations in neocortical circuits and are in turn controlled by neuromodulation. While a detailed understanding of the distinct marker expression, physiology, and neuromodulator responses of different interneuron types exists for rodents and recent studies have highlighted the role of specific interneurons in converting rapid neuromodulatory signals into altered sensory processing during locomotion, attention, and associative learning, it remains little understood whether similar mechanisms exist in human neocortex. Here, we use whole-cell recordings combined with agonist application, transgenic mouse lines, in situ hybridization, and unbiased clustering to directly determine these features in human layer 1 interneurons (L1-INs). Our results indicate pronounced nicotinic recruitment of all L1-INs, whereas only a small subset co-expresses the ionotropic HTR3 receptor. In addition to human specializations, we observe two comparable physiologically and genetically distinct L1-IN types in both species, together indicating conserved rapid neuromodulation of human neocortical circuits through layer 1.
KW  - cell types
KW  - evolution
KW  - genetic markers
KW  - human neocortex
KW  - interneuron types
KW  - layer 1 interneurons
KW  - mouse neocortex
KW  - neocortical circuits
KW  - neuromodulation
KW  - translation
KW  - whole-cell recordings
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51113
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-511137
SN  - 2211-1247
N1  - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 23
IS  - 4
SP  - 951
EP  - 958
PB  - Cell Press ; Elsevier
CY  - Maryland Heights, MO ; [New York, NY]
ER  -