TY  - JOUR
A1  - Lötsch, Jörn
A1  - Walter, Carmen
A1  - Zunftmeister, Martin
A1  - Zinn, Sebastian
A1  - Wolters, Miriam
A1  - Ferreirós Bouzas, Nerea
A1  - Rossmanith, Tanja
A1  - Oertel, Bruno Georg
A1  - Geisslinger, Gerd
T1  - A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects
T2  - Basic & Clinical Pharmacology & Toxicology
N2  - Persistent and, in particular, neuropathic pain is a major healthcare problem with still insufficient pharmacological treatment options. This triggered research activities aimed at finding analgesics with a novel mechanism of action. Results of these efforts will need to pass through the phases of drug development, in which experimental human pain models are established components e.g. implemented as chemical hyperalgesia induced by capsaicin. We aimed at ranking the various readouts of a human capsaicin–based pain model with respect to the most relevant information about the effects of a potential reference analgesic. In a placebo‐controlled, randomized cross‐over study, seven different pain‐related readouts were acquired in 16 healthy individuals before and after oral administration of 300 mg pregabalin. The sizes of the effect on pain induced by intradermal injection of capsaicin were quantified by calculating Cohen's d. While in four of the seven pain‐related parameters, pregabalin provided a small effect judged by values of Cohen's d exceeding 0.2, an item categorization technique implemented as computed ABC analysis identified the pain intensities in the area of secondary hyperalgesia and of allodynia as the most suitable parameters to quantify the analgesic effects of pregabalin. Results of this study provide further support for the ability of the intradermal capsaicin pain model to show analgesic effects of pregabalin. Results can serve as a basis for the designs of studies where the inclusion of this particular pain model and pregabalin is planned.
KW  - analgesia
KW  - data science
KW  - human pain models
KW  - human pharmacology
KW  - pain
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57421
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-574216
SN  - 1742-7843
VL  - 126.2020
IS  - 4
SP  - 318
EP  - 331
PB  - Wiley-Blackwell
CY  - Oxford
ER  -