TY  - JOUR
A1  - Diehl, Valentina
A1  - Huber, Lisa Sophie
A1  - Trebicka, Jonel
A1  - Wygrecka, Małgorzata
A1  - Iozzo, Renato V.
A1  - Schäfer, Liliana
T1  - The role of decorin and biglycan signaling in tumorigenesis
T2  - Frontiers in oncology
N2  - The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. In their soluble forms, decorin and biglycan act as powerful signaling molecules. By receptor-mediated signal transduction, both proteoglycans modulate key processes vital for tumor initiation and progression, such as autophagy, inflammation, cell-cycle, apoptosis, and angiogenesis. Despite of their structural homology, these two proteoglycans interact with distinct cell surface receptors and thus modulate distinct signaling pathways that ultimately affect cancer development. In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and address potential novel therapeutic implications.
KW  - extracellular matrix
KW  - proteoglycan
KW  - autophagy
KW  - inflammation
KW  - angiogenesis
KW  - cancer
KW  - toll-like receptor
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62058
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-620587
SN  - 2234-943X
N1  - The authors’ laboratories were supported by the German Research Council (SFB 1039, project B02, SFB 1177, 259130777, project E02, all to LS; and the CardioPulmonary Institute (CPI), EXC 2026, Project ID: 390649896 (to LS and MW); WY119/1-3 (to MW), the Else Kroner-Fresenius-Foundation (to MW), and the German Center for Lung Research (to MW);¨ European Union’s Horizon 2020 research and innovation program’s MICROBPREDICT study (No 825694), European Union’s Horizon 2020 Research and Innovation Program GALAXY (No. 668031) and Societal Challenges LIVERHOPE (Health, demographic change, and well-being, No. 731875) the German Research Council (SFB TRR57, CRC1382), Cellex Foundation (PREDICT) all to JT. The original research in Dr. Iozzo laboratory was supported in part by National Institutes of Health Grants RO1 CA39481 and RO1 CA245311.
VL  - 11
IS  - art. 801801
SP  - 1
EP  - 17
PB  - Frontiers Media
CY  - Lausanne
ER  -